[Modification of the effect of fotrin in phenobarbital-induced metabolic system].

Abstract

Random bred male rats were given drinking water with phenobarbital (PB) (daily doses 0.4; 2 and 10 mg/kg) during 120 days. Activity of mixed function of oxygenases (content of cytochromes P-450) were enhanced after PB treatment in doses 2 and 10 mg/kg. Following PB treatment the animals were injected 5-times ethyleneimine derivate--fotrin at the doses 2, 4 and 7 mg/kg. The induction of mixed function of oxygenases resulted in significant decrease in the number of cells with chromosome aberrations.

• Authors: V S Zhurkov, L P Sycheva, N P Burmantova
• Journal: Biulleten' eksperimental'noi biologii i meditsiny (Biull Eksp Biol Med) Vol. 106 Issue 10 Pg. 458-60 (Oct 1988) ISSN: 0365-9615 [Print] Russia (Federation)
• Vernacular Title: Modifikatsiia éffekta fotrina na fone induktsii sistemy metabolizma fenobarbitalom.
• PMID: 3191238 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Aziridines
• Azirines
• Mutagens
• fotrin
• Cytochrome P-450 Enzyme System
• Mixed Function Oxygenases
• Phenobarbital

Topics

• Animals
• Aziridines (pharmacology)
• Azirines (pharmacology)
• Bone Marrow (drug effects, ultrastructure)
• Chromosome Aberrations
• Cytochrome P-450 Enzyme System (biosynthesis)
• Enzyme Induction (drug effects)
• Male
• Mixed Function Oxygenases (biosynthesis)
• Mutagens (pharmacology)
• Phenobarbital (pharmacology)
• Rats