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benzene 1,2,3-tricarboxylic acid
structure given in first source; inhibits phosphoenolpyruvate carboxykinase
Also Known As:
1,2,3-benzenetricarboxylate; 1,2,3-benzyltricarboxylate; benzene 1,2,3-tricarboxylic acid, copper salt
Networked:
4
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Hydrocarbons: 1713
Cyclic Hydrocarbons: 97
Aromatic Hydrocarbons: 291
Benzene Derivatives: 17
benzene 1,2,3-tricarboxylic acid: 4
Carboxylic Acids: 973
Acyclic Acids
Tricarboxylic Acids: 423
benzene 1,2,3-tricarboxylic acid: 4
Related Diseases
1.
Neoplasms (Cancer)
01/01/1986 - "
Furthermore, we have demonstrated that the more rapid citrate efflux kinetics (catalyzed by the tricarboxylate exchange carrier) of isolated tumor mitochondria is completely inhibited upon addition of 1,2,3-benzenetricarboxylate (BTC) and have shown that this inhibition is apparently also obtained in viable tumor tissue when the inhibitor is added to the tissue incubation.
"
04/29/1986 - "
However, the presence of the mitochondrial citrate exchange carrier inhibitor 1,2,3-benzenetricarboxylate in the incubation inhibited the formation of [14C]cholesterol, while simultaneously leading to an increase in the rate of 14CO2 production in the tumor.
"
08/25/1984 - "
Blocking the tricarboxylate anion exchange carrier with the citrate transport inhibitor 1,2,3-benzenetricarboxylate restores the ability of tumor 3924A mitochondria to respire with pyruvate or citrate.
"
2.
Lymphoma (Lymphomas)
02/01/1989 - "
When citrate export from mitochondria is blocked with 1,2,3-benzenetricarboxylate (BTC) during the G1/S phase of the cell cycle, both DNA synthesis and cell growth are dramatically inhibited in suspension-grown 70Z/3 murine lymphoma cell cultures sustained under otherwise optimal conditions.
"
Related Drugs and Biologics
1.
Citric Acid (Citrate)
2.
Pyruvic Acid (Pyruvate)
3.
Suspensions
4.
DNA (Deoxyribonucleic Acid)
5.
Cholesterol
6.
Anions