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PDI inhibitor 16f16

Also Known As:

16f16

Networked: 7 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - PDI inhibitor 16f16: 7

Experts

1.	Ishino, Kousuke: 1 article (01/2021)
2.	Kaneya, Yohei: 1 article (01/2021)
3.	Kondo, Ryota: 1 article (01/2021)
4.	Kudo, Mitsuhiro: 1 article (01/2021)
5.	Kure, Shoko: 1 article (01/2021)
6.	Naito, Zenya: 1 article (01/2021)
7.	Ohashi, Ryuji: 1 article (01/2021)
8.	Takata, Hideyuki: 1 article (01/2021)
9.	Taniai, Nobuhiko: 1 article (01/2021)
10.	Wada, Ryuichi: 1 article (01/2021)

Related Diseases

1.	Neuroblastoma 01/01/2020 - "This study investigated the molecular implications of PDI inhibition by examining the effect of the PDI inhibitors securinine and 16F16 on the gene expression profile of SH-SY5Y neuroblastoma cells. "
2.	Liver Neoplasms (Liver Cancer) 01/01/2021 - "The aim of the present study was to elucidate the usefulness of combination treatment with Ev and 16F16 in liver cancer using cultured Li-7 and HuH-6 cells. " 01/01/2021 - "Combination treatment with Ev and 16F16 could be a novel therapeutic strategy for liver cancer." 01/01/2021 - "The small molecule 16F16 increased susceptibility to Ev in cultured liver cancer cells, which are resistant to Ev. The inhibition was associated with reduction of 4E-BP1 phosphorylation, which formed a complex with PDIA3. " 01/01/2021 - "Inhibitor for protein disulfide-isomerase family A member 3 enhances the antiproliferative effect of inhibitor for mechanistic target of rapamycin in liver cancer: An in vitro study on combination treatment with everolimus and 16F16."
3.	Breast Neoplasms (Breast Cancer) 01/01/2023 - "We show that either prior PDIA3 inhibition by the disulfide isomerase inhibitor 16F16 or depletion of heparin-binding proteins strongly reduces the activity of conditioned medium (CM) of MDA-MB-231 human breast cancer cells to support promigratory cell spreading and F-actin organization by newly adherent MDA-MB-231 cells. " 01/01/2019 - "We present the evidence which proves that highly metastatic MDA-MB-231 breast cancer cell lines adhere to endothelial cells are more effective than non-invasive MCF-10A and MCF-7 cell lines and that the attachment of MDA-MB-231 to the endothelium can be attenuated either by the agents blocking free thiol groups (DTNB, cystamine or PCMBS) or by PDI inhibitors (Q3Rut, 16F16 or PACMA-31). "
4.	Human Influenza (Influenza) 01/01/2018 - "Among PDI inhibitors, 16F16, PACMA31, isoquercetin, epigallocatechin-3-gallate or nitazoxanide significantly reduced the replication of influenza A and B viruses in MDCK and A549 cells. "
5.	Infections 12/31/2020 - "In agreement with this observation, the PDI inhibitor 16F16 strongly blocked infection by HAstV serotypes 1 and 8, but not serotype 2. RNA interference of PDIA4 expression selectively blocked HAstV-8 infectivity. "

Related Drugs and Biologics

1.	Protein Disulfide-Isomerases
2.	Sirolimus (Rapamycin)
3.	Everolimus
4.	securinine
5.	PACMA-31
6.	Conditioned Culture Media
7.	Sulfhydryl Compounds (Thiols)
8.	Heparin (Liquaemin)
9.	Dithionitrobenzoic Acid (Ellman's Reagent)
10.	Cystamine