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ARN22089

Also Known As:

N1,N1-dimethyl-N3-(6-phenyl-2-(piperidin-4-yl)pyrimidin-4-yl)benzene-1,3-diamine

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Polyamines: 3918
    - Diamines: 518
      - ARN22089: 2

Experts

1.	Acquistapace, Isabella Maria: 1 article (01/2022)
2.	Arencibia, Jose M: 1 article (01/2022)
3.	Armirotti, Andrea: 1 article (01/2022)
4.	Bertorelli, Rosalia: 1 article (01/2022)
5.	Bertozzi, Sine Mandrup: 1 article (01/2022)
6.	Brindani, Nicoletta: 1 article (01/2022)
7.	Chen, Chi-Fen: 1 article (01/2022)
8.	De Vivo, Marco: 1 article (01/2022)
9.	Edwards, Robert: 1 article (01/2022)
10.	Flesher, Jessica L: 1 article (01/2022)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2023 - "ARN22089 also inhibits tumor angiogenesis in three-dimensional vascularized microtumor models in vitro. " 01/01/2022 - "Here, we use computer-aided drug design to discover a chemical entity (ARN22089) that has broad activity against a panel of cancer cell lines, inhibits S6 phosphorylation and MAPK activation, activates pro-inflammatory and apoptotic signaling, and blocks tumor growth and angiogenesis in 3D vascularized microtumor models (VMT) in vitro. " 01/01/2023 - "ARN22089 blocks tumor growth in BRAF mutant mouse melanoma models and patient-derived xenografts (PDXs) in vivo. "
2.	Melanoma (Melanoma, Malignant) 01/01/2022 - "Additionally, ARN22089 has a favorable pharmacokinetic profile and can inhibit the growth of BRAF mutant mouse melanomas and patient-derived xenografts in vivo. " 01/01/2023 - "ARN22089 blocks tumor growth in BRAF mutant mouse melanoma models and patient-derived xenografts (PDXs) in vivo. "