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TXA709

Carboxamide prodrug of TXA707.

Also Known As:

N-(2,6-difluoro-3-((6-(trifluoromethyl)-(1,3)thiazolo(5,4-b)pyridin-2-yl)methoxy)benzoyl)-1-methylpiperidine-4-carboxamide

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Pharmaceutical Preparations
- Prodrugs: 8091
  - TXA709: 3
Organic Chemicals: 133
- Sulfur Compounds: 278
  - Thiazoles: 392
    - TXA709: 3
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Thiazoles: 392
      - TXA709: 3

Experts

1.	Kaul, Malvika: 1 article (01/2016)
2.	LaVoie, Edmond J: 1 article (01/2016)
3.	Mark, Lilly: 1 article (01/2016)
4.	Parhi, Ajit K: 1 article (01/2016)
5.	Pilch, Daniel S: 1 article (01/2016)

Related Diseases

1.	Infections 10/01/2022 - "Co-administration with TXA709 renders oxacillin efficacious in mouse models of both systemic and tissue infection with MRSA, with this efficacy being observed at human-equivalent doses of oxacillin well below that recommended for daily adult use. " 01/01/2016 - "We also demonstrate synergy in vivo with oral administration of the prodrug TXA709 and cefdinir in mouse models of both systemic and tissue (thigh) infections with MRSA. " 01/01/2023 - "Significantly, both intravenously and orally administered TXH1033 exhibited enhanced in vivo efficacy relative to the carboxamide prodrug of TXA707 (TXA709) in treating a mouse model of systemic (peritonitis) MRSA infection. "
2.	Staphylococcal Infections 01/01/2016 - "Viewed as a whole, our results highlight the potential of TXA709 and cefdinir as a promising combination for the treatment of drug-resistant staphylococcal infections."
3.	Peritonitis 01/01/2023 - "Significantly, both intravenously and orally administered TXH1033 exhibited enhanced in vivo efficacy relative to the carboxamide prodrug of TXA707 (TXA709) in treating a mouse model of systemic (peritonitis) MRSA infection. "

Related Drugs and Biologics

1.	Prodrugs
2.	Oxacillin (Prostaphlin)
3.	Cefdinir (Omnicef)
4.	TXA707

Related Therapies and Procedures

1.	Oral Administration