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piperlonguminine

Also Known As:

2,4-pentadienamide, 5-(1,3-benzodioxol-5-yl)-n-(2-methylpropyl)-, (2E,4E); piperlonguminin

Networked: 18 relevant articles (3 outcomes, 4 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Dioxoles
    - Benzodioxoles: 3
      - piperlonguminine: 18
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzodioxoles: 3
      - piperlonguminine: 18

Experts

1.	Kim, Jeong Ah: 4 articles (08/2014 - 12/2004)
2.	Lee, Seung Ho: 3 articles (08/2014 - 12/2004)
3.	Bae, Jong-Sup: 2 articles (08/2014 - 08/2013)
4.	Jee, Jun-Goo: 2 articles (08/2014 - 08/2013)
5.	Lee, Min Young: 2 articles (08/2014 - 08/2013)
6.	Lee, Sangkyu: 2 articles (08/2014 - 08/2013)
7.	Kim, Kyeong-Soo: 2 articles (02/2006 - 12/2004)
8.	Kim, Youngsoo: 2 articles (02/2006 - 12/2004)
9.	Min, Kyung Rak: 2 articles (02/2006 - 12/2004)
10.	Hang, Jiaying: 1 article (01/2021)

Related Diseases

1.	Parkinson Disease (Parkinson's Disease) 10/01/2011 - "showed protective effects on Parkinson's disease models in our previous study and piperine and piperlonguminine were the two main constituents in the alkaloids. "
2.	Inflammation (Inflammations) 08/01/2013 - "Barrier protective effects of piperlonguminine in LPS-induced inflammation in vitro and in vivo." 03/28/2008 - "Taken together, the results indicate that the amide fractions piperovatine and piperlonguminine showed the greatest inhibitory activity of topical inflammation induced by croton oil." 01/01/2022 - "In LHQW, arctiin, corymbosin, and aloe-emodin target neurological disease-related genes (GRM1 and GRM5), whereas in QFPD, isofucosterol, baicalein, nobiletin, oroxylin A, epiberberine, and piperlonguminine target immunity- and inflammation-related genes (mTOR and PLA2G4A). "
3.	Ischemia 11/01/2020 - "Activation of ALDH2 by piperlonguminine ameliorates cell damage generated in heart ischemia/reperfusion events, by decreasing lipid aldehydes concentration promoting cardioprotection."
4.	Experimental Melanoma 12/01/2004 - "Piperlonguminine from Piper longum with inhibitory effects on alpha-melanocyte-stimulating hormone-induced melanogenesis in melanoma B16 cells." 02/01/2006 - "Surprisingly, piperlonguminine did not inhibit the catalytic activity of cell-free tyrosinase from melanoma B16 cells but rather suppressed tyrosinase mRNA expression. " 02/01/2006 - "Inhibitory effect of piperlonguminine on melanin production in melanoma B16 cell line by downregulation of tyrosinase expression." 02/01/2006 - "In the present study, piperlonguminine from Piper longum was discovered to inhibit melanin production in melanoma B16 cells stimulated with alpha-melanocyte stimulating hormone (alpha-MSH), 3-isobutyl-1-methylxanthine or protoporphyrin IX, where the compound exhibited stronger depigmenting efficacy than kojic acid. "
5.	Lung Injury 03/20/2023 - "The aim of this study was to explore the therapeutic potential of piperlonguminine on SAP-induced lung injury in rat models. " 03/20/2023 - "Together, our findings demonstrate for the first time that piperlonguminine can ameliorate acute pancreatitis-induced lung injury via inhibitory modulation of inflammatory responses by suppression of the TLR4/NF-κB signaling pathway." 03/20/2023 - "Effects of piperlonguminine on lung injury in severe acute pancreatitis <em>via</em> the TLR4/NF-κB pathway."

Related Drugs and Biologics

1.	Alkaloids
2.	piperine
3.	Lipids
4.	Aldehydes
5.	alpha-MSH
6.	1-Methyl-3-isobutylxanthine (1 Methyl 3 isobutylxanthine)
7.	Melanins (Melanin)
8.	protoporphyrin IX
9.	kojic acid
10.	Amides