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SPA70

A potent and selective hPXR antagonist.

Also Known As:

4-(4-tert-butylbenzenesulfonyl)-1-(2,5-dimethoxyphenyl)-5-methyl-1H-1,2,3-triazole

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Triazoles: 1533
      - SPA70: 2

Experts

1.	Chai, Sergio C: 1 article (01/2017)
2.	Chen, Taosheng: 1 article (01/2017)
3.	Griffin, Patrick R: 1 article (01/2017)
4.	Lin, Wenwei: 1 article (01/2017)
5.	Lv, Lili: 1 article (01/2017)
6.	Wang, Yong-Dong: 1 article (01/2017)
7.	Wang, Yue-Ming: 1 article (01/2017)
8.	Wu, Jing: 1 article (01/2017)
9.	Zhang, Qijun: 1 article (01/2017)
10.	Zheng, Jie: 1 article (01/2017)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2017 - "SPA70 inhibits hPXR in human hepatocytes and humanized mouse models and enhances the chemosensitivity of cancer cells, consistent with the role of hPXR in drug resistance. " 10/01/2022 - "Combination of PXT and SPA70 dramatically inhibited tumor growth in a paclitaxel-resistant A549/TR xenograft tumor model. "
2.	Lung Neoplasms (Lung Cancer) 10/01/2022 - "The combination regimen of PTX and SPA70 could be potential novel candidates for the treatment of taxane-resistant lung cancer." 10/01/2022 - "In vitro, SPA70 and PTX synergistically inhibited cell growth, migration and invasion in both paclitaxel-sensitive and paclitaxel-resistant A549 and H460 lung cancer cells. "
3.	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 10/01/2022 - "Combination of Paclitaxel and PXR Antagonist SPA70 Reverses Paclitaxel-Resistant Non-Small Cell Lung Cancer."

Related Drugs and Biologics

1.	Paclitaxel (Taxol)
2.	taxane