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olpasiran

an siRNA targeting lipoprotein(a)

Networked: 3 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Nucleic Acids, Nucleotides, and Nucleosides: 1
- Nucleic Acids: 11752
  - RNA: 69704
    - Untranslated RNA: 2850
      - Small Untranslated RNA: 566
        Small Interfering RNA: 25779
        olpasiran: 3
    - Antisense RNA: 1599
      - Small Interfering RNA: 25779
        olpasiran: 3
- Antisense Elements (Genetics): 31
  - Antisense RNA: 1599
    - Small Interfering RNA: 25779
      - olpasiran: 3

Related Diseases

1.	Myocardial Infarction 07/01/2023 - "The ongoing Olpasiran Trials of Cardiovascular Events and Lipoprotein(a) Reduction [OCEAN(a)]-Outcomes trial is evaluating whether Lp(a) lowering can reduce the incidence of cardiovascular events among patients with prior myocardial infarction (MI) or percutaneous coronary intervention (PCI) and elevated Lp(a) (≥200 nmol/L). "
2.	Cardiovascular Diseases (Cardiovascular Disease) 11/17/2022 - "Longer and larger trials will be necessary to determine the effect of olpasiran therapy on cardiovascular disease. " 11/17/2022 - "Olpasiran therapy significantly reduced lipoprotein(a) concentrations in patients with established atherosclerotic cardiovascular disease. "
3.	Dyslipidemias (Dyslipidemia) 09/01/2023 - "Recent biotechnological advances have led to the development of innovative small molecules (bempedoic acid, lomitapide, pemafibrate, docosapentaenoic and eicosapentaenoic acid), antibodies (evinacumab), antisense oligonucleotides (mipomersen, volanesorsen, pelcarsen, olezarsen), small interfering RNA (inclisiran, olpasiran), and gene therapies for patients with dyslipidemia. "
4.	Pain (Aches) 11/17/2022 - "The most common olpasiran-related adverse events were injection-site reactions, primarily pain. "
5.	Injection Site Reaction 11/17/2022 - "The most common olpasiran-related adverse events were injection-site reactions, primarily pain. "

Related Drugs and Biologics

1.	Lipoprotein(a)
2.	Small Interfering RNA (siRNA)
3.	Antisense Oligonucleotides
4.	Eicosapentaenoic Acid
5.	Antibodies
6.	ALN-PCS
7.	8- hydroxy- 2,2,14,14- tetramethylpentadecanedioic acid
8.	(R)-2-(3-((benzoxazol-2-yl-d4 (3- (4- methoxyphenoxy- d7)propyl)amino)methyl)phenoxy) butanoic acid
9.	mipomersen
10.	BMS201038

Related Therapies and Procedures

1.	Therapeutics
2.	Percutaneous Coronary Intervention