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ML111

Also Known As:

2-amino-4-(3-methoxyphenyl)-4H-benzo(h)chromene-3-carbonitrile

Networked: 1 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - Benzopyrans: 195
      - ML111: 1
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzopyrans: 195
      - ML111: 1
Organic Chemicals: 133
- Nitriles: 227
  - ML111: 1

Experts

1.	Davare, Monika A: 1 article (09/2021)
2.	Esfandiari Nazzaro, Ellie: 1 article (09/2021)
3.	Gafken, Philip R: 1 article (09/2021)
4.	Leid, Mark: 1 article (09/2021)
5.	Nazari, Mohamad: 1 article (09/2021)
6.	Nicholson, Katelyn S: 1 article (09/2021)
7.	Sabei, Fahad Y: 1 article (09/2021)
8.	Taratula, Oleh: 1 article (09/2021)
9.	Taratula, Olena: 1 article (09/2021)
10.	Vogel, Walter K: 1 article (09/2021)

Related Diseases

1.	Ewing Sarcoma (Sarcoma, Ewing) 09/24/2021 - "These results suggest that ML111 represents a promising new drug lead for further preclinical studies and is a potential clinical development for the treatment of Ewing's sarcoma." 09/24/2021 - "Proteomic studies show that ML111 treatment induced prometaphase arrest followed by rapid caspase-dependent apoptotic cell death in Ewing's sarcoma cell lines. " 09/24/2021 - "By using high-throughput phenotypic screening of small molecule libraries, we identified a previously uncharacterized compound (ML111) that inhibited in vitro proliferation of six established Ewing's sarcoma cell lines with nanomolar potency. " 09/24/2021 - "ML111, delivered via methoxypoly(ethylene glycol)-polycaprolactone copolymer nanoparticles, induced dose-dependent inhibition of Ewing's sarcoma tumor growth in a murine xenograft model and invoked prometaphase arrest in vivo, consistent with in vitro data. "
2.	Neoplasms (Cancer) 09/24/2021 - "ML111, delivered via methoxypoly(ethylene glycol)-polycaprolactone copolymer nanoparticles, induced dose-dependent inhibition of Ewing's sarcoma tumor growth in a murine xenograft model and invoked prometaphase arrest in vivo, consistent with in vitro data. "

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