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AMPK activator O304

Sci Rep . 2021 Dec 23;11(1):24410.

Also Known As:

AMP-activated protein kinase activator O304; AMPK activator O-304

Networked: 4 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Sulfur Compounds: 278
  - Thiazoles: 392
    - Thiadiazoles: 99
      - AMPK activator O304: 4
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Thiazoles: 392
      - Thiadiazoles: 99
        AMPK activator O304: 4

Experts

1.	Edlund, Helena: 2 articles (11/2021 - 01/2018)
2.	Ericsson, Madelene: 2 articles (11/2021 - 01/2018)
3.	Steneberg, Pär: 2 articles (11/2021 - 01/2018)
4.	Nyrén, Rakel: 1 article (11/2021)
5.	Buvanendran, Asokumar: 1 article (06/2019)
6.	Das, Vaskar: 1 article (06/2019)
7.	Kroin, Jeffrey S: 1 article (06/2019)
8.	McCarthy, Robert J: 1 article (06/2019)
9.	Moric, Mario: 1 article (06/2019)
10.	Backlund, Fredrik: 1 article (01/2018)

Related Diseases

1.	Insulin Resistance 11/18/2021 - "Here we show that the pan-AMPK activator O304, which is well tolerated in humans, prevented and reverted age-associated hyperinsulinemia and insulin resistance, and improved cardiac function and exercise capacity in aged mice. "
2.	Hyperinsulinism (Hyperinsulinemia) 11/18/2021 - "Here we show that the pan-AMPK activator O304, which is well tolerated in humans, prevented and reverted age-associated hyperinsulinemia and insulin resistance, and improved cardiac function and exercise capacity in aged mice. "
3.	Hypersensitivity (Allergy) 06/21/2019 - "This study examines if postsurgery treatment with the prototype AMPK activator metformin and a new mechanism-specific AMPK activator, O304, after plantar hindpaw incision in mice, would reduce mechanical hypersensitivity and produce changes in the AMPK pathway in the dorsal root ganglion (DRG). " 06/21/2019 - "Early treatment with the mechanism-specific AMPK activator O304 or the prototype AMPK activator metformin reduces mechanical hypersensitivity in a postoperative pain model in mice. "
4.	Hyperalgesia 12/01/2022 - "The direct peripheral AMPK activator O304 reduced allodynia in a dose-dependent manner, and immunoblot studies of the DRG showed that O304 increased p-AMPK and decreased TRPA1, p-ERK1/2, as well as translation factors involved in neuroplasticity. "
5.	Postoperative Pain 06/21/2019 - "Early treatment with the mechanism-specific AMPK activator O304 or the prototype AMPK activator metformin reduces mechanical hypersensitivity in a postoperative pain model in mice. "

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