galactosyl-deficient IgA1

01/01/2023 - "The disease is characterized by haematuria, proteinuria, deposition of galactose-deficient IgA1 in the glomerular mesangium and mesangial hypercellularity, further leading to extracellular matrix expansion. "
06/02/2022 - "Even in Japanese patients with IgAN and trace proteinuria (less than 0.3 g/gCr), urinary Gd-IgA1 was detected. "
01/01/2021 - "In addition, levels of factor Ba and Gd-IgA1 were positively associated with proteinuria and negatively associated with renal function. "
01/01/2021 - "Among the four groups, we did not observe significant correlations of Gd-IgA1 levels with eGFR, proteinuria, or the MEST-C score. "
04/01/2019 - "There was no significant correlation between serum Gd-IgA1 levels and proteinuria or estimated glomerular filtration rate at diagnosis. "

10/13/2023 - "The study intended to explore whether the LPS/TLR4 pathway regulates mesenteric B cells, secreting Gd-IgA1 to induce IgA nephropathy. "
07/21/2022 - "Our prior study indicates a close relationship between alternative complement pathway activation, galactose-deficient IgA1 (Gd-IgA1) concentration and clinical severity of IgA nephropathy (IgAN). "
01/01/2022 - "The aim of this study was to evaluate the interactions among serum levels of galactose-deficient IgA1 (Gd-IgA1), oxidative stress and macrophage infiltration and their clinical correlates in patients with IgA Nephropathy (IgAN). "
08/01/2018 - "Assay for galactose-deficient IgA1 enables mechanistic studies with primary cells from IgA nephropathy patients."
01/01/2014 - "Recent studies have shown that galactose-deficient IgA1 (GdIgA1) has an important role in the pathogenesis of IgA nephropathy (IgAN). "

05/01/2020 - "To study the role of follicular helper T (Tfh) cells and galactose-deficient IgA1 (Gd-IgA1) in the pathogenesis of childhood Henoch-Schönlein purpura (HSP) and the correlation between them. "
05/01/2020 - "[Expression and significance of follicular helper T cells and galactose-deficient IgA1 in children with Henoch-Schönlein purpura]."
02/01/2019 - "To explore the value of galactose-deficient IgA1 (Gd-IgA1) in the early diagnosis of Henoch-Schönlein purpura nephritis (HSPN) in children. "
02/01/2019 - "[Value of galactose-deficient IgA1 in the early diagnosis of Henoch-Schönlein purpura nephritis in children]."
07/01/2011 - "In this paper, we determined the heritability of serum Gd-IgA1 levels in children with IgAN and Henoch-Schönlein purpura nephritis (HSPN), two disorders with clinical phenotypes sharing common pathogenic mechanisms. "

12/01/2017 - "Although Gd-IgA1 complexes are also present in patients with IgAV with nephritis, their role in IgAV is disputed. "
01/01/2023 - "Moreover, patients with IgAN had similar levels of serum Gd-IgA1 compared to first-degree relatives (SMD=0.38, 95% CI= -0.04-0.81, P=0.08) and IgA vasculitis with nephritis patients (SMD=0.12, 95% CI= -0.04-0.29, P=0.14). "
02/01/2019 - "To explore the value of galactose-deficient IgA1 (Gd-IgA1) in the early diagnosis of Henoch-Schönlein purpura nephritis (HSPN) in children. "
02/01/2019 - "[Value of galactose-deficient IgA1 in the early diagnosis of Henoch-Schönlein purpura nephritis in children]."
01/01/2018 - "GDIgA1 (galactose deficient IgA1) plays a significant role in the pathogenesis of IgA nephropathy (IgAN) and Henoch-Schönlein nephritis (HSN). "

04/01/2019 - "The disease progression with worse renal outcome in patients with higher serum Gd-IgA1 may be therefore mediated by more pronounced mesangial cell inflammatory response leading to more severe histologic changes."
07/01/2017 - "Gd-IgA1 levels were elevated in IgAN patients compared with ethnically matched healthy subjects and correlated with evidence of disease progression. "
10/01/2012 - "The level of galactose-deficient IgA1 in the sera of patients with IgA nephropathy is associated with disease progression."
05/01/2021 - "The value of circulating Gd-IgA1 measured by the monoclonal antibody KM55 is related to a worse evolution of patients with IgAN independently of other variables, so it could be included in the study of patients to improve the prediction of the risk of disease progression."
05/01/2021 - "The value of circulating Gd-IgA1 measured by the monoclonal antibody KM55 is related to a worse evolution of patients with IgAN independently of other variables, so it could be included in the study of patients to improve the prediction of the risk of disease progression."