tubocapsenolide A

anti-tumor component isolated from Tubocapsicum anomalum

Also Known As:

(1S,2R,6S,7R,9R,11R,14R,15S)-15-((1S)-1-((2R)-4,5-dimethyl-6-oxo-2,3-dihydropyran-2-yl)ethyl)-6,14-dihydroxy-2,15-dimethyl-8-oxapentacyclo(9.7.0.02,7.07,9.012,16)octadeca-4,12(16)-dien-3-one

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - tubocapsenolide A: 4

Experts

1.	Chen, Chen: 2 articles (12/2021 - 01/2021)
2.	Kong, Lingyi: 2 articles (12/2021 - 01/2021)
3.	Luo, Jianguang: 2 articles (12/2021 - 01/2021)
4.	Wang, Sibei: 2 articles (12/2021 - 01/2021)
5.	Zhu, Dongrong: 2 articles (12/2021 - 01/2021)
6.	Zhu, Jiangmin: 2 articles (12/2021 - 01/2021)
7.	Chang, Fang-Rong: 2 articles (01/2012 - 06/2008)
8.	Chen, Wen-Ying: 2 articles (01/2012 - 06/2008)
9.	Wu, Chin-Chung: 2 articles (01/2012 - 06/2008)
10.	Wu, Yang-Chang: 2 articles (01/2012 - 06/2008)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2021 - "Tubocapsenolide A (TA) is an anti-tumor component isolated from Tubocapsicum anomalum. " 12/01/2021 - "Previously, we have reported a withanolide-type steroid, named tubocapsenolide A (TA), which shows potent anti-proliferative activity in several cancer cell lines. " 01/01/2021 - "Tubocapsenolide A targets C-terminal cysteine residues of HSP90 to exert the anti-tumor effect." 06/20/2008 - "Tubocapsenolide A (TA), a novel withanolide-type steroid, exhibits potent cytotoxicity against several human cancer cell lines. "
2.	Osteosarcoma (Osteogenic Sarcoma) 12/01/2021 - "Osteosarcoma cell proliferation suppression via SHP-2-mediated inactivation of the JAK/STAT3 pathway by tubocapsenolide A."
3.	Breast Neoplasms (Breast Cancer) 01/01/2012 - "We have previously demonstrated that a withanolide, tubocapsenolide A, induced cycle arrest and apoptosis in human breast cancer cells, which was associated with the inhibition of heat shock protein 90 (Hsp90). "

Related Drugs and Biologics

1.	Steroids
2.	Heat-Shock Proteins (Heat-Shock Protein)
3.	Cysteine (L-Cysteine)