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SMU-Z1

TLR1-2 agonist

Also Known As:

2-(1-(2-(methylamino)-5-nitrophenyl)-1H-imidazol-4-yl)-5-(trifluoromethyl)phenol

Networked: 2 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Imidazoles: 150
      - SMU-Z1: 2
Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Phenols: 677
        SMU-Z1: 2

Experts

1.	Cheng, Kui: 2 articles (10/2021 - 05/2019)
2.	Liu, Shuwen: 2 articles (10/2021 - 05/2019)
3.	Duan, Siqin: 1 article (10/2021)
4.	Huang, Liwen: 1 article (10/2021)
5.	Peng, Jie: 1 article (10/2021)
6.	Wang, Jinshen: 1 article (10/2021)
7.	Xu, Xinfeng: 1 article (10/2021)
8.	Yu, Tao: 1 article (10/2021)
9.	Zhou, Yang: 1 article (10/2021)
10.	Cen, Xiaohong: 1 article (05/2019)

Related Diseases

1.	Shock 10/01/2021 - "To identify a new approach for eradicating the HIV latent reservoir, we evaluated the effectiveness of SMU-Z1, a novel small-molecule TLR1/2 agonist, in the "shock-and-kill" strategy. " 10/01/2021 - "We showed that SMU-Z1 displayed dual potential ex vivo in the shock of exposure of latently HIV-1-infected cells and in the kill of clearance of infected cells, which is critical for effective use in combination with therapeutic vaccines or broadly neutralizing antibody treatments aimed at curing AIDS."
2.	Acquired Immunodeficiency Syndrome (AIDS) 10/01/2021 - "We showed that SMU-Z1 displayed dual potential ex vivo in the shock of exposure of latently HIV-1-infected cells and in the kill of clearance of infected cells, which is critical for effective use in combination with therapeutic vaccines or broadly neutralizing antibody treatments aimed at curing AIDS."
3.	Neoplasms (Cancer) 05/17/2019 - "Finally, the induced tumors in three out of seven mice disappear after administration of SMU-Z1. "
4.	Leukemia 05/17/2019 - "In addition, SMU-Z1 promotes murine splenocyte proliferation and upregulates the expression of CD8+ T cells, NK cells and DCs, which results in a significant antitumor effect in a murine leukemia model. "

Related Drugs and Biologics

1.	Vaccines
2.	Broadly Neutralizing Antibodies