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DFX24

PI3Kalpha inhibitor

Also Known As:

2,4-difluoro-N-(2-methoxy-5-(3-(3-morpholinopropyl)-4-oxo-3,4-dihydroquinazolin-6-yl)pyridin-3-yl)benzenesulfonamide

Networked: 1 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Ding, Huai-Wei: 1 article (10/2020)
2.	Fan, Yan-Hua: 1 article (10/2020)
3.	Hong, Ji-Young: 1 article (10/2020)
4.	Kim, Donghwa: 1 article (10/2020)
5.	Lee, Sang Kook: 1 article (10/2020)
6.	Liu, Jian-Yu: 1 article (10/2020)
7.	Wang, Daoping: 1 article (10/2020)
8.	Xu, Yong-Nan: 1 article (10/2020)
9.	Yang, Xiao-Sheng: 1 article (10/2020)

Related Diseases

1.	Neoplasm Metastasis (Metastasis) 10/01/2020 - "In the present study, we developed a novel quinazolin-4(3H)-one analog (DFX24) as a potential PI3Kα inhibitor, which inhibited both cell proliferation and metastasis of NSCLC cell lines. " 10/01/2020 - "Investigation to the molecular mechanisms revealed DFX24 inhibited the cell growth and metastasis via inhibition of PI3Kα and ERK activity, as well as the increase in EPHB6 expression. " 10/01/2020 - "The PI3Kα inhibitor DFX24 suppresses tumor growth and metastasis in non-small cell lung cancer via ERK inhibition and EPHB6 reactivation."
2.	Neoplasms (Cancer) 10/01/2020 - "In addition, DFX24 also induced cell cycle arrest and tumor cell apoptosis by inhibiting PI3K/Akt pathway and activating mitochondria-dependent pathway, respectively. " 10/01/2020 - "The PI3Kα inhibitor DFX24 suppresses tumor growth and metastasis in non-small cell lung cancer via ERK inhibition and EPHB6 reactivation."
3.	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 10/01/2020 - "The PI3Kα inhibitor DFX24 suppresses tumor growth and metastasis in non-small cell lung cancer via ERK inhibition and EPHB6 reactivation."