ACT001

01/01/2020 - "The in vivo efficacy of ACT001 was evaluated in GL261 murine glioma model. "
10/07/2019 - "In this study, we investigated the effects of ACT001 on glioma cell proliferation and clarified its mechanism. "
01/01/2021 - "Methods: The effects of ACT001 on cell survival of normal human astrocytes (NHA) and patient-derived glioma stem-like cells (GSCs) were evaluated. "
01/01/2020 - "Conclusion: Our results demonstrate that STAT3 plays a key role in immunosuppression of glioma and is inhibited by ACT001. "
01/01/2020 - "Western blotting, RT-PCR and immunofluorescence were used to detect PD-L1 and p-STAT3 expression in glioma cells exposed to ACT001. "

08/01/2023 - "In vivo, ACT001 (400 mg/kg/day) inhibited PDAC tumor growth in orthotopic xenograft mice. "
02/02/2023 - "ACT001, a natural compound derivative, has shown anti-tumor activity in various cancers. "
01/01/2020 - "Our results suggest that ACT001 exerts its anticancer effects by inducing apoptosis in murine TNBC cell line 4T1 and regulates the tumor microenvironment by attenuating angiogenesis and accumulation of MDSCs in 4T1 tumors. "
01/01/2020 - "ACT001 effectively suppressed the growth of U-118 MG tumors in BALB/c nude mice and GL-261-luciferase tumors in C57BL/6 J mice. "
01/01/2020 - "However, few studies have investigated the anticancer effects of ACT001 in triple-negative breast cancer (TNBC), a highly aggressive cancer with a poor prognosis. "

07/01/2023 - "ACT001 Ameliorates ionizing radiation-induced lung injury by inhibiting NLRP3 inflammasome pathway."

01/01/2022 - "ACT001 relieved the extent of blood-brain barrier integrity damage and alleviated motor function deficits after TBI via reducing trauma-induced activation of microglia cells. "

09/01/2022 - "ACT001 was also effective in suppressing the growth of different subtypes of human pituitary adenomas. "
09/01/2022 - "Here, we demonstrated that ACT001 suppressed cell proliferation and induced cell death of pituitary tumor cells in vitro and in vivo. "
09/01/2022 - "ACT001 inhibits pituitary tumor growth by inducing autophagic cell death via MEK4/MAPK pathway."