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ERDRP-0519

Also Known As:

2-methyl-N-(4-((2S)-2-(2-morpholin-4-ylethyl)piperidin-1-yl)sulfonylphenyl)-5-(trifluoromethyl)pyrazole-3-carboxamide

Networked: 2 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds

Experts

1.	Cox, Robert M: 2 articles (01/2021 - 01/2021)
2.	Natchus, Michael G: 2 articles (01/2021 - 01/2021)
3.	Plemper, Richard K: 2 articles (01/2021 - 01/2021)
4.	Anderson, Danielle E: 1 article (01/2021)
5.	Govindarajan, Mugunthan: 1 article (01/2021)
6.	Kolkykhalov, Alexander A: 1 article (01/2021)
7.	Mankertz, Annette: 1 article (01/2021)
8.	Pfaller, Christian K: 1 article (01/2021)
9.	Pfeffermann, Kristin: 1 article (01/2021)
10.	Plesker, Roland: 1 article (01/2021)

Related Diseases

1.	Measles 01/01/2021 - "We demonstrate that prophylactic and post-exposure therapeutic treatment with an orally bioavailable small-molecule polymerase inhibitor, ERDRP-0519, prevents measles disease in squirrel monkeys (Saimiri sciureus). " 01/01/2021 - "ERDRP-0519, a pan-morbillivirus small molecule inhibitor for the treatment of measles, targets the morbillivirus RNA-dependent RNA-polymerase (RdRP) complex and displayed unparalleled oral efficacy against lethal infection of ferrets with CDV, an established surrogate model for human measles. " 01/01/2021 - "This study informs selection of ERDRP-0519 as clinical candidate for measles therapy and identifies a previously unrecognized druggable site in mononegavirus L polymerase proteins that can silence all synthesis of viral RNA."
2.	Infections 01/01/2021 - "ERDRP-0519, a pan-morbillivirus small molecule inhibitor for the treatment of measles, targets the morbillivirus RNA-dependent RNA-polymerase (RdRP) complex and displayed unparalleled oral efficacy against lethal infection of ferrets with CDV, an established surrogate model for human measles. "

Related Drugs and Biologics

1.	RNA-Dependent RNA Polymerase (RNA Dependent RNA Polymerase)
2.	Viral RNA
3.	Proteins (Proteins, Gene)

Related Therapies and Procedures

1.	Therapeutics