avian vacuolar myelinopathy

avian CNS disease in which myelin degeneration in the white matter are seen in waterfowls, bald eagles. avian vacuolar myelinopathy is linked to CYANOBACTERIAL NEUROTOXINS (e.g., ETOKTHONOTOXIN; L-BMAA).

Also Known As:

Networked: 6 relevant articles (0 outcomes, 1 trials/studies)

Disease Context: Research Results

Experts

1.	Niedermeyer, Timo H J: 2 articles (08/2021 - 01/2021)
2.	Adak, Sanjoy: 1 article (01/2022)
3.	Lukowski, April L: 1 article (01/2022)
4.	Moore, Bradley S: 1 article (01/2022)
5.	Schäfer, Rebecca J B: 1 article (01/2022)
6.	Llanes, Dayma: 1 article (08/2021)
7.	Ricardo, Manuel G: 1 article (08/2021)
8.	Schwark, Markus: 1 article (08/2021)
9.	Westermann, Bernhard: 1 article (08/2021)
10.	Breinlinger, Steffen: 1 article (01/2021)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to avian vacuolar myelinopathy:

1.	aetokthonotoxinIBA 01/01/2021 - "Recent studies have demonstrated that vacuolar myelinopathy is induced by consumption of the epiphytic cyanobacterial species Aetokthonos hydrillicola growing on aquatic vegetation, primarily the invasive Hydrilla verticillata Here, we describe the identification, biosynthetic gene cluster, and biological activity of aetokthonotoxin, a pentabrominated biindole alkaloid that is produced by the cyanobacterium A. " 10/03/2023 - "The freshwater epiphytic cyanobacterium Aetokthonos hydrillicola has recently been shown to produce the "eagle killer" neurotoxin aetokthonotoxin (AETX) causing the fatal neurological disease vacuolar myelinopathy. " 01/01/2022 - "Aetokthonotoxin (AETX) is a cyanobacterial neurotoxin that causes vacuolar myelinopathy, a neurological disease that is particularly deadly to bald eagles in the United States. " 08/19/2021 - "Aetokthonotoxin has recently been identified as the cyanobacterial neurotoxin causing Vacuolar Myelinopathy, a fatal neurologic disease, spreading through a trophic cascade and affecting birds of prey such as the bald eagle in the USA. " 08/19/2021 - "Total Synthesis of Aetokthonotoxin, the Cyanobacterial Neurotoxin Causing Vacuolar Myelinopathy."
2.	AlkaloidsIBA 01/01/2021 - "Recent studies have demonstrated that vacuolar myelinopathy is induced by consumption of the epiphytic cyanobacterial species Aetokthonos hydrillicola growing on aquatic vegetation, primarily the invasive Hydrilla verticillata Here, we describe the identification, biosynthetic gene cluster, and biological activity of aetokthonotoxin, a pentabrominated biindole alkaloid that is produced by the cyanobacterium A. "
3.	Cyanobacteria ToxinsIBA 01/01/2021 - "Hunting the eagle killer: A cyanobacterial neurotoxin causes vacuolar myelinopathy." 01/01/2022 - "Aetokthonotoxin (AETX) is a cyanobacterial neurotoxin that causes vacuolar myelinopathy, a neurological disease that is particularly deadly to bald eagles in the United States. " 08/19/2021 - "Aetokthonotoxin has recently been identified as the cyanobacterial neurotoxin causing Vacuolar Myelinopathy, a fatal neurologic disease, spreading through a trophic cascade and affecting birds of prey such as the bald eagle in the USA. " 08/19/2021 - "Total Synthesis of Aetokthonotoxin, the Cyanobacterial Neurotoxin Causing Vacuolar Myelinopathy." 01/01/2021 - "hydrillicola We identify this cyanobacterial neurotoxin as the causal agent of vacuolar myelinopathy and discuss environmental factors-especially bromide availability-that promote toxin production."
4.	VigabatrinFDA Link 12/01/2009 - "Pathological evidence of vacuolar myelinopathy in a child following vigabatrin administration."
5.	Proteins (Proteins, Gene)FDA Link 01/01/2015 - "Furthermore, genetic alterations of mitochondrial genome or nuclear genes encoding proteins playing essential roles in maintaining proper mitochondrial function can lead to the development of severe systemic diseases associated with neurodegeneration and vacuolar myelinopathy. "
6.	NeurotoxinsIBA 10/03/2023 - "The freshwater epiphytic cyanobacterium Aetokthonos hydrillicola has recently been shown to produce the "eagle killer" neurotoxin aetokthonotoxin (AETX) causing the fatal neurological disease vacuolar myelinopathy. "
7.	BromidesIBA 01/01/2021 - "hydrillicola We identify this cyanobacterial neurotoxin as the causal agent of vacuolar myelinopathy and discuss environmental factors-especially bromide availability-that promote toxin production."