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mebrofenin

Also Known As:

((((3-Bromomesityl)carbamoyl)methyl)imino)diacetic acid; SQ 26962; SQ-26962; glycine, N-(2-((3-bromo-2,4,6-trimethylphenyl)amino)-2-oxoethyl)-N-(carboxymethyl)-

Networked: 38 relevant articles (3 outcomes, 4 trials/studies)

Relationship Network

Drug Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Aniline Compounds: 46
    - mebrofenin: 38
Amino Acids, Peptides, and Proteins: 1
- Amino Acids: 30675
  - Glycine: 5151
    - mebrofenin: 38

Experts

1.	Bhargava, Kuldeep K: 3 articles (02/2009 - 02/2002)
2.	Gupta, Sanjeev: 3 articles (02/2009 - 02/2002)
3.	Palestro, Christopher J: 3 articles (02/2009 - 02/2002)
4.	Bennink, Roelof J: 2 articles (01/2013 - 10/2006)
5.	van Gulik, Thomas M: 2 articles (01/2013 - 10/2006)
6.	Joseph, Brigid: 2 articles (02/2009 - 04/2008)
7.	Tronco, Gene G: 2 articles (02/2009 - 04/2008)
8.	Aguilera-Hernández, Estrella: 1 article (12/2022)
9.	Cardoza-Ochoa, David R: 1 article (12/2022)
10.	González-Díaz, Jorge Iván: 1 article (12/2022)

Related Diseases

1.	Inflammation (Inflammations) 02/01/2009 - "Fractional retention of peak hepatic mebrofenin activity over 60-min periods was correlated with parameters of hepatic inflammation. " 04/01/2008 - "The remarkable sensitivity of mebrofenin excretion to cytokines suggests that Tc-mebrofenin imaging will be helpful for assessing cytokine-mediated liver inflammation." 08/01/1999 - "The results show that these mice have cholestasis with conjugated hyperbilirubinemia, failure to excrete technetium-labeled mebrofenin from the liver into the small intestine, lack of continuity between the extrahepatic biliary tree and the small intestine as demonstrated by Trypan blue cholangiography, and a liver histological picture indicative of extrahepatic biliary obstruction with negligible inflammation/necrosis within the hepatic parenchyma. "
2.	Hepatitis 09/23/2022 - "Quantitative Assessment of Liver Impairment in Chronic Viral Hepatitis with [99mTc]Tc-Mebrofenin: A Noninvasive Attempt to Stage Viral Hepatitis-Associated Liver Fibrosis." 07/01/2003 - "Hepatobiliary clearance of labelled mebrofenin in normal and D-galactosamine HCl-induced hepatitis rats and the protective effect of turmeric extract."
3.	Cholestasis 03/01/2011 - "Using intravenously administered technetium Tc 99m-labeled mebrofenin, the distribution of bile during periods of biochemical cholestasis and in remission was investigated in patients with PFIC operated with PEBD. " 08/01/1999 - "The results show that these mice have cholestasis with conjugated hyperbilirubinemia, failure to excrete technetium-labeled mebrofenin from the liver into the small intestine, lack of continuity between the extrahepatic biliary tree and the small intestine as demonstrated by Trypan blue cholangiography, and a liver histological picture indicative of extrahepatic biliary obstruction with negligible inflammation/necrosis within the hepatic parenchyma. "
4.	Liver Cirrhosis (Hepatic Cirrhosis) 09/23/2022 - "Conclusions-Our present study proves that conducting dynamic liver scintigraphies with [99mTc]Tc-mebrofenin has potential value in staging liver fibrosis. " 04/01/2010 - "The assessment of hepatobiliary function by Tc-mebrofenin scintigraphy may be a good choice for assessing the severity of liver fibrosis in patients with HCV." 09/23/2022 - "Quantitative Assessment of Liver Impairment in Chronic Viral Hepatitis with [99mTc]Tc-Mebrofenin: A Noninvasive Attempt to Stage Viral Hepatitis-Associated Liver Fibrosis." 04/01/2010 - "The aim of this study was to evaluate the utility of hepatobiliary function through technetium-99m-N-(-3-bromo-2,4,6-trimethylacetanilide) iminodiacetic acid (Tc-mebrofenin) scintigraphy in evaluating liver fibrosis in patients with chronic HCV infection. "
5.	Liver Diseases (Liver Disease) 02/01/2002 - "Although the data were obtained in an animal model of Wilson' disease, these biochemical parameters likely reflect liver damage in general, suggesting that there may be a role for mebrofenin scintigraphy in other chronic liver diseases as well." 07/01/2002 - "The main aim of this study was to investigate the role of N-(2,4,6 trimethyl-3-bromophenylcarbamoylmethyl) iminodiacetic acid (IDA; Mebrofenin) scintigraphy in follow-up assessments of the biliary system in patients with cystic fibrosis associated liver disease. "

Related Drugs and Biologics

1.	Technetium (Technetium 99m)
2.	Cytokines
3.	Galactosamine
4.	turmeric extract
5.	iminodiacetic acid
6.	Phenobarbital (Luminal)
7.	Radiopharmaceuticals
8.	Radioisotopes (Radionuclides)
9.	Acids
10.	Trypan Blue

Related Therapies and Procedures

1.	Cholecystectomy
2.	Transjugular Intrahepatic Portasystemic Shunt
3.	Hepatectomy