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dual inhibitor PTUPB

COX-2-sEH dual inhibitor

Also Known As:

1-(3-(5-phenyl-1-(4-sulfamoylphenyl)pyrazol-3-yl)propyl)-3-(4-(trifluoromethyl)phenyl)urea

Networked: 6 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Pyrazoles: 61
      - dual inhibitor PTUPB: 6
Organic Chemicals: 133
- Amides: 2428
  - Sulfonamides: 2809
    - dual inhibitor PTUPB: 6
- Sulfur Compounds: 278
  - Sulfones: 534
    - Sulfonamides: 2809
      - dual inhibitor PTUPB: 6

Experts

1.	Hammock, Bruce D: 5 articles (01/2021 - 10/2017)
2.	Hwang, Sung Hee: 5 articles (01/2021 - 10/2017)
3.	Duan, Jia-Xi: 3 articles (06/2020 - 01/2020)
4.	Guan, Cha-Xiang: 3 articles (06/2020 - 01/2020)
5.	Guan, Xin-Xin: 3 articles (06/2020 - 01/2020)
6.	Sun, Chen-Chen: 3 articles (06/2020 - 01/2020)
7.	Yang, Hui-Hui: 3 articles (06/2020 - 01/2020)
8.	Zhang, Chen-Yu: 3 articles (06/2020 - 01/2020)
9.	Zhong, Wen-Jing: 3 articles (06/2020 - 01/2020)
10.	Zhou, Yong: 3 articles (06/2020 - 01/2020)

Related Diseases

1.	Sepsis (Septicemia) 06/01/2020 - "A COX-2/sEH dual inhibitor PTUPB ameliorates cecal ligation and puncture-induced sepsis in mice via anti-inflammation and anti-oxidative stress."
2.	Inflammation (Inflammations) 06/01/2020 - "A COX-2/sEH dual inhibitor PTUPB ameliorates cecal ligation and puncture-induced sepsis in mice via anti-inflammation and anti-oxidative stress."
3.	Acute Lung Injury 01/01/2020 - "A COX-2/sEH dual inhibitor PTUPB alleviates lipopolysaccharide-induced acute lung injury in mice by inhibiting NLRP3 inflammasome activation."
4.	Pulmonary Fibrosis (Fibrosing Alveolitis) 01/01/2020 - "COX-2/sEH dual inhibitor PTUPB alleviates bleomycin-induced pulmonary fibrosis in mice via inhibiting senescence."
5.	Neoplasms (Cancer) 10/20/2017 - "Cyclooxygenase-2 (COX-2)/soluble epoxide hydrolase (sEH) dual inhibitor, PTUPB, has been demonstrated to inhibit angiogenesis, primary tumor growth and metastasis. "

Related Drugs and Biologics

1.	ErbB Receptors (EGF Receptor)
2.	Inflammasomes
3.	Cyclooxygenase 2 (Cyclooxygenase-2)
4.	Lipopolysaccharides
5.	Epoxide Hydrolases
6.	Bleomycin (Blenoxane)
7.	hyaluronan-mediated motility receptor

Related Therapies and Procedures

1.	Punctures
2.	Ligation