5- (4- hydroxyphenyl)- 3H- 1,2- dithiole- 3- thione

07/01/2022 - "In this study, we investigated the antimetastatic effects of ADT-OH in highly metastatic melanoma cells. "
07/01/2022 - "Collectively, these results demonstrate that ADT-OH inhibits the EMT process in melanoma cells by suppressing the CSE/CBS and FAK signaling pathways, thereby exerting its antimetastatic activity. "
07/01/2022 - "In addition, ADT-OH significantly suppressed the proliferation of melanoma cells. "
07/01/2022 - "Overexpression of FAK reversed the inhibitory effects of ADT-OH on melanoma cell migration. "
07/01/2022 - "We further showed that ADT-OH dose-dependently inhibited the migration and invasion of B16F10, B16F1 and A375 melanoma cells as evaluated by wound healing and Transwell assays in vitro. "

01/01/2020 - "Taken together, our data suggest that ADT-OH is a promising cancer therapeutic drug that warrants further investigation into its potential clinical applications."
01/01/2020 - "As expected, tumour-specific delivery of FADD through a recombinant Salmonella strain, VNP-FADD, combined with low-dose ADT-OH treatment significantly inhibited tumour growth and induced cancer cell apoptosis. "
01/01/2023 - "27 novel 5-(4-hydroxyphenyl)-3H-1,2-dithiole-3-thione derivatives of brefeldin A were designed and synthesized to make them more conducive to the cancer treatment. "
11/01/2015 - "The PAM-PGlyADT micelles show comparable toxicity with ADT-OH in different cancer cell lines, whereas the PAM-PIleADT micelles are not toxic up to 400 µM. "
01/01/2023 - "In recent studies, 5-(4-hydroxyphenyl)-3H-1,2-dithiole-3-thione (ADT-OH), one of the most commonly used reagents for the synthesis of sustained-release H2 S donors, has also been reported to inhibit cancer progression by affecting processes such as cell cycle, angiogenesis, and apoptosis. "

07/29/2023 - "ADT-OH improves intestinal barrier function and remodels the gut microbiota in DSS-induced colitis."
07/29/2023 - "We found that ADT-OH effectively reduced the DSS-colitis clinical score and reversed the inflammation-induced shortening of colon length. "
07/29/2023 - "Transplanting ADT-OH-modulated microbiota can alleviate DSS-induced colitis and negatively regulate the expression of local and systemic proinflammatory cytokines. "
04/01/2007 - "Treatment with ADT-OH, the H(2)S-releasing moiety of ATB-429, did not affect severity of colitis. "

07/29/2023 - "In addition, ADT-OH restored intestinal microbiota dysbiosis characterized by the significantly increased abundance of Muribaculaceae and Alistipes and markedly decreased abundance of Helicobacter, Mucispirillum, Parasutterella, and Desulfovibrio. "

01/01/2016 - "In a mouse model of middle cerebral artery occlusion (MCAO), intravenous injection of tPA enhanced cerebral hemorrhage, which was significantly attenuated by the co-administration of two structurally unrelated H2S donors, ADT-OH and NaHS. "