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ACH-000029

modulates 5-HT and alpha1-adrenergic receptors

Also Known As:

3-(2-(4-(2-methoxyphenyl) piperazine-1-yl) ethyl) quinazoline-4(3H)-one

Networked: 3 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Piperazines: 26
    - ACH-000029: 3
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinazolines: 402
      - ACH-000029: 3

Experts

1.	Azevedo, Hatylas: 3 articles (11/2020 - 12/2019)
2.	Ferreira, Marcos: 3 articles (11/2020 - 12/2019)
3.	Mascarello, Alessandra: 3 articles (11/2020 - 12/2019)
4.	Guimarães, Cristiano Ruch Werneck: 2 articles (11/2020 - 12/2019)
5.	Osten, Pavel: 2 articles (11/2020 - 01/2020)
6.	Werneck Guimarães, Cristiano Ruch: 1 article (01/2020)
7.	Costa, Renata Watanabe: 1 article (12/2019)
8.	Russo, Elisa: 1 article (12/2019)
9.	Russo, Valter: 1 article (12/2019)

Related Diseases

1.	Post-Traumatic Stress Disorders (Post Traumatic Stress Disorder) 01/01/2020 - "Here, we investigated the potential of ACH-000029 to prevent anxiety-like behavior in the single prolonged stress (SPS) PTSD model. " 01/01/2020 - "The serotonergic and alpha-1 adrenergic receptor modulator ACH-000029 ameliorates anxiety-like behavior in a post-traumatic stress disorder model." 01/01/2020 - "These results support the hypothesis that the dual regulation of 5-HT and α1-adrenergic receptors is required to alleviate PTSD symptoms and suggest a possible role of ACH-000029 as a PTSD treatment." 11/01/2020 - "Finally, the dual regulation of serotonin and α1 receptors by ACH-000029 might represent a potential pharmacotherapy that can be applied in the peri-trauma or early post-trauma period to mitigate the development of symptoms in PTSD patients."
2.	Wounds and Injuries (Trauma) 11/01/2020 - "Finally, the dual regulation of serotonin and α1 receptors by ACH-000029 might represent a potential pharmacotherapy that can be applied in the peri-trauma or early post-trauma period to mitigate the development of symptoms in PTSD patients."
3.	Anxiety Disorders (Anxiety Disorder) 12/20/2019 - "This work supports the further development of ACH-000029 as a drug candidate for the treatment of anxiety disorders. "

Related Drugs and Biologics

1.	alpha-1 Adrenergic Receptors (alpha 1 Adrenergic Receptor)
2.	Serotonin (5 Hydroxytryptamine)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)