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mevociclib

CDK7 inhibitor

Also Known As:

N-((1S,3R)-3-((5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl)amino)-1-methylcyclohexyl)-5-(((E)-4-(dimethylamino)but-2-enoyl)amino)pyridine-2-carboxamide; SY-1365

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 510
    - mevociclib: 2
  - Pyridines: 88
    - mevociclib: 2

Experts

1.	Lallena, María José: 1 article (10/2019)
2.	Sanfeliciano, Sonia Gutiérrez: 1 article (10/2019)
3.	Sánchez-Martínez, Concepción: 1 article (10/2019)
4.	de Dios, Alfonso: 1 article (10/2019)
5.	Alnemy, Sydney R: 1 article (01/2019)
6.	Bradley, Michael J: 1 article (01/2019)
7.	Carulli, John P: 1 article (01/2019)
8.	Choi, Yoon Jong: 1 article (01/2019)
9.	Ciblat, Stephane: 1 article (01/2019)
10.	Fritz, Christian C: 1 article (01/2019)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 01/01/2019 - "Here, we describe a selective CDK7 inhibitor SY-1365, which is currently in clinical trials in populations of patients with ovarian and breast cancer (NCT03134638). "
2.	Neoplasms (Cancer) 10/15/2019 - "SY-1365, a CDK7 inhibitor has shown initial encouraging data in phase I for solid tumors treatment. " 01/01/2019 - "In vitro, SY-1365 inhibited cell growth of many different cancer types at nanomolar concentrations. " 01/01/2019 - "Antitumor activity was also observed in xenograft models of ovarian cancer, suggesting the potential for exploring SY-1365 in the clinic in both hematologic and solid tumors. " 01/01/2019 - "SY-1365 treatment decreased MCL1 protein levels, and cancer cells with low BCL2L1 (BCL-XL) expression were found to be more sensitive to SY-1365. "
3.	Ovarian Neoplasms (Ovarian Cancer) 01/01/2019 - "Antitumor activity was also observed in xenograft models of ovarian cancer, suggesting the potential for exploring SY-1365 in the clinic in both hematologic and solid tumors. "

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