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CMLD-2

Hu antigen R (HuR) inhibitor

Also Known As:

5,7-dimethoxy-8-(1-(4-methoxyphenyl)-3-oxo-3-(pyrrolidin-1-yl)propyl)-4-phenyl-2H-chromen-2-one

Networked: 3 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - Benzopyrans: 195
      - CMLD-2: 3
  - Pyrrolidines: 115
    - CMLD-2: 3
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzopyrans: 195
      - CMLD-2: 3

Experts

1.	Aubé, Jeffrey: 2 articles (01/2019 - 01/2017)
2.	Roy, Sudeshna: 2 articles (01/2019 - 01/2017)
3.	Allegri, Lorenzo: 1 article (01/2019)
4.	Baldan, Federica: 1 article (01/2019)
5.	Damante, Giuseppe: 1 article (01/2019)
6.	Filetti, Sebastiano: 1 article (01/2019)
7.	Russo, Diego: 1 article (01/2019)
8.	Ahmed, Rebaz: 1 article (01/2017)
9.	Chen, Allshine: 1 article (01/2017)
10.	Herman, Terence: 1 article (01/2017)

Related Diseases

1.	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/01/2017 - "In this study, we examined the antitumor activity of CMLD-2, a small-molecule inhibitor directed against HuR, using non-small cell lung cancer (NSCLC) as a model. "
2.	Neoplasms (Cancer) 01/01/2019 - "CMLD-2 treatment induced a strong MAD2 downregulation and rescue experiments depicted it as a key effector in HuR-mediated in cancer. " 01/01/2017 - "Finally, CMLD-2 treatment resulted in greater mitochondrial perturbation, activation of caspase-9 and -3 and cleavage of PARP in tumor cells compared to normal cells. " 01/01/2017 - "CMLD-2 decreased HuR mRNA and the mRNAs of HuR-regulated proteins (Bcl2 and p27) in tumor cells. "
3.	Thyroid Neoplasms (Thyroid Cancer) 01/01/2019 - "Here, we examined the antitumor effects of CMLD-2 in four thyroid cancer cell lines (SW1736, 8505 C, BCPAP and K1). " 01/01/2019 - "The HuR CMLD-2 inhibitor exhibits antitumor effects via MAD2 downregulation in thyroid cancer cells."
4.	Lung Neoplasms (Lung Cancer) 01/01/2017 - "Our proof-of concept study results demonstrate CMLD-2 represents a promising HuR-targeted therapeutic class that with further development could lead to advanced preclinical studied and ultimately for lung cancer treatment."
5.	Hyperalgesia 12/07/2022 - "Peripheral administration of CMLD-2 in the paw or genetic elimination of HuR from sensory neurons diminished behavioral responses associated with NGF- and IL-6-induced allodynia in male and female mice. "

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