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isotonitazene

synthetic opioid

Networked: 7 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzimidazoles: 245
      - isotonitazene: 7

Experts

1.	Basile, Giuseppe: 1 article (11/2022)
2.	Lo Faro, Alfredo Fabrizio: 1 article (11/2022)
3.	Napoletano, Simona: 1 article (11/2022)
4.	Negro, Francesca: 1 article (11/2022)
5.	Archer, John R H: 1 article (02/2022)
6.	Blundell, Matthew S: 1 article (02/2022)
7.	Dargan, Paul I: 1 article (02/2022)
8.	De Baerdemaeker, Klara S C: 1 article (02/2022)
9.	Dines, Alison M: 1 article (02/2022)
10.	Hudson, Simon: 1 article (02/2022)

Related Diseases

1.	Opiate Overdose 11/01/2022 - "That being said, significantly more substances were implicated in isotonitazene-related deaths than fatalities linked to other synthetic opioid overdose (4, 5). " 09/01/2021 - "Isotonitazene was involved in a substantial minority of synthetic opioid overdose deaths in the first 7 months of 2020. " 02/24/2023 - "Isotonitazene, a novel psychoactive substance opioid, detected in two cases following a local surge in opioid overdoses." 11/01/2022 - "Case reports have highlighted how flualprazolam was detected in most fatalities associated with isotonitazene whereas flualprazolam was involved in only 8% of other synthetic opioid overdose deaths (3). "
2.	Drug-Related Side Effects and Adverse Reactions 02/24/2023 - "There have been no reports of the detection of isotonitazene in patients presenting to the emergency department with acute drug toxicity. "
3.	Respiratory Insufficiency (Respiratory Failure) 07/21/2023 - "Both isotonitazene and N-desethyl isotonitazene show high potency in mouse analgesia tail-flick assays, but N-desethyl isotonitazene shows longer-lasting respiratory depression compared to fentanyl. "
4.	Poisoning 04/01/2023 - "However, iso-etonitazene and iso-isotonitazene showed moderate activity similar to that of fentanyl, indicating that these drugs could cause poisoning at a comparable level as fentanyl, if these drugs are abused in the future."
5.	Pica (Geophagia) 11/01/2022 - "Of 88 included NPS, 34 (mitragynine, flualprazolam, 3F/4F-α-P(i)HP, etizolam, 4F-MDMB-BINACA, cyproheptadine, 5F-MDMB-PICA, isotonitazene, isohexedrone, MDPEP, N-ethylpentedrone, tianeptine, flubromazolam, 4'-methylhexedrone, α-P(i)HP, eutylone, mephedrone, N-ethylhexedrone, 5F-MDMB-PINACA, ADB-BUTINACA, 3-methoxy PCP, 4F-furanylfentanyl, 4F-isobuturylfentanyl, acrylfentanyl, furanylfentanyl, clonazolam, norfludiazepam, 3F-phenmetrazine, 3-MMC, 4-methylpentedrone, BMDP, ethylphenidate, methylone and α-PVP) were identified as 219 findings in 84 patients. "

Related Drugs and Biologics

1.	Fentanyl (Sublimaze)
2.	flualprazolam
3.	Phenmetrazine (Preludin)
4.	Cyproheptadine (Periactin)
5.	Opioid Analgesics (Opioids)
6.	mephedrone
7.	methylone
8.	etonitazene
9.	tianeptine (Stablon)
10.	etizolam

Related Therapies and Procedures

1.	Analgesia