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branebrutinib

Also Known As:

4-((3S)-3-(2-Butynoylamino)-1-piperidinyl)-5-fluoro-2,3-dimethyl-1H-indole-7-carboxamide; BMS-986195

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Piperidines: 17
    - branebrutinib: 3
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - branebrutinib: 3

Experts

1.	Siess, Wolfgang: 1 article (03/2021)
2.	von Hundelshausen, Philipp: 1 article (03/2021)
3.	Ambudkar, Suresh V: 1 article (01/2021)
4.	Chi, Ya-Chen: 1 article (01/2021)
5.	Hsiao, Sung-Han: 1 article (01/2021)
6.	Huang, Yang-Hui: 1 article (01/2021)
7.	Hung, Tai-Ho: 1 article (01/2021)
8.	Murakami, Megumi: 1 article (01/2021)
9.	Wu, Chung-Pu: 1 article (01/2021)
10.	Wu, Yu-Shan: 1 article (01/2021)

Related Diseases

1.	Rheumatoid Arthritis 01/01/2019 - "This strategy has been successfully applied to the measurement of the RO for Bruton's tyrosine kinase (BTK) in the blood lysate of monkeys after dosing with branebrutinib (BMS-986195), a covalent BTK inhibitor being evaluated to treat rheumatoid arthritis. " 03/04/2021 - "These include the brain-penetrant irreversible tolebrutinib and evobrutinib (against multiple sclerosis), the irreversible branebrutinib, the reversible BMS-986142 and fenebrutinib (targeting rheumatoid arthritis and lupus erythematodes), and the reversible covalent rilzabrutinib (against pemphigus and immune thrombocytopenia). "
2.	Idiopathic Thrombocytopenic Purpura (Thrombocytopenic Purpura, Autoimmune) 03/04/2021 - "These include the brain-penetrant irreversible tolebrutinib and evobrutinib (against multiple sclerosis), the irreversible branebrutinib, the reversible BMS-986142 and fenebrutinib (targeting rheumatoid arthritis and lupus erythematodes), and the reversible covalent rilzabrutinib (against pemphigus and immune thrombocytopenia). "
3.	Pemphigus (Pemphigus Vulgaris) 03/04/2021 - "These include the brain-penetrant irreversible tolebrutinib and evobrutinib (against multiple sclerosis), the irreversible branebrutinib, the reversible BMS-986142 and fenebrutinib (targeting rheumatoid arthritis and lupus erythematodes), and the reversible covalent rilzabrutinib (against pemphigus and immune thrombocytopenia). "
4.	Neoplasms (Cancer) 01/01/2021 - "In addition, we found that branebrutinib is equally cytotoxic to drug-sensitive parental cell lines and the respective P-gp-overexpressing multidrug-resistant variants, suggesting that it is unlikely that the overexpression of P-gp in cancer cells plays a significant role in reduced susceptibility or resistance to branebrutinib. " 01/01/2021 - "In the present work, we explored the prospect of repositioning branebrutinib (BMS-986195), a highly selective inhibitor of Bruton's tyrosine kinase (BTK), to resensitize P-gp-overexpressing multidrug-resistant cancer cells to chemotherapeutic agents. " 01/01/2021 - "Branebrutinib (BMS-986195), a Bruton's Tyrosine Kinase Inhibitor, Resensitizes P-Glycoprotein-Overexpressing Multidrug-Resistant Cancer Cells to Chemotherapeutic Agents."
5.	Multiple Sclerosis 03/04/2021 - "These include the brain-penetrant irreversible tolebrutinib and evobrutinib (against multiple sclerosis), the irreversible branebrutinib, the reversible BMS-986142 and fenebrutinib (targeting rheumatoid arthritis and lupus erythematodes), and the reversible covalent rilzabrutinib (against pemphigus and immune thrombocytopenia). "

Related Drugs and Biologics

1.	Agammaglobulinaemia Tyrosine Kinase
2.	Member 1 Subfamily B ATP Binding Cassette Transporter
3.	evobrutinib
4.	fenebrutinib