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PhenDC3

G-quadruplex ligand structurally unrelated to heme

Networked: 3 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Polycyclic Compounds: 6
- Fused-Ring Compounds
  - PhenDC3: 3

Experts

1.	Molnár, Orsolya Réka: 1 article (12/2021)
2.	Smeller, László: 1 article (12/2021)
3.	Somkuti, Judit: 1 article (12/2021)
4.	Végh, András: 1 article (12/2021)
5.	Campello, Maria Paula Cabral: 1 article (01/2021)
6.	Capranico, Giovanni: 1 article (01/2021)
7.	Carvalho, Josué: 1 article (01/2021)
8.	Cruz, Carla: 1 article (01/2021)
9.	Duardo, Renée C: 1 article (01/2021)
10.	Lopes-Nunes, Jéssica: 1 article (01/2021)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2021 - "The studied G4 binders (pyridostatin and PhenDC3) can induce an increase of micronuclei triggering the activation of the cytoplasmic STING (stimulator of interferon response cGAMP interactor 1) signaling pathway in human and murine cancer cells. " 12/01/2021 - "Study of three ligands designed in cancer research for GQ targeting (TMPyP4, BRACO19 and PhenDC3) showed unequivocally their binding to HepB. "
2.	Virus Diseases (Viral Diseases) 01/01/2021 - "A sequence found in high-risk HPV16 genotype folds into multiple non-canonical DNA structures; it was converted into a major G4 conformation upon interaction with a well-characterized highly selective G4 ligand, PhenDC3, which may have an impact on the viral infection. "
3.	Bites and Stings (Sting) 01/01/2021 - "The studied G4 binders (pyridostatin and PhenDC3) can induce an increase of micronuclei triggering the activation of the cytoplasmic STING (stimulator of interferon response cGAMP interactor 1) signaling pathway in human and murine cancer cells. "

Related Drugs and Biologics

1.	Ligands
2.	BRACO-19
3.	tetra(4-N-methylpyridyl)porphine
4.	gamma- hydroxy- gamma- ethyl- gamma- phenylbutyramide (HEPB)
5.	Interferons
6.	DNA (Deoxyribonucleic Acid)
7.	cyclic guanosine monophosphate-adenosine monophosphate
8.	pyridostatin