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ZL0454

selective BRD4 inhibitor

Also Known As:

(E)-4-((2-amino-4-hydroxy-5-methylphenyl)diazenyl)-N-cyclopentylbenzenesulfonamide

Networked: 3 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133

Experts

1.	Brasier, Allan R: 3 articles (01/2019 - 01/2019)
2.	Liu, Zhiqing: 3 articles (01/2019 - 01/2019)
3.	Tian, Bing: 3 articles (01/2019 - 01/2019)
4.	Zhou, Jia: 3 articles (01/2019 - 01/2019)
5.	Calhoun, William J: 2 articles (01/2019 - 01/2019)
6.	Kaphalia, Lata: 2 articles (01/2019 - 01/2019)
7.	Maroto, Rosario: 2 articles (01/2019 - 01/2019)
8.	Motamedi, Massoud: 2 articles (01/2019 - 01/2019)
9.	Rytting, Erik: 2 articles (01/2019 - 01/2019)
10.	Sun, Hong: 2 articles (01/2019 - 01/2019)

Related Diseases

1.	Airway Remodeling 01/01/2019 - "We therefore tested two novel highly selective BRD4 inhibitors, ZL0420 and ZL0454, for their effects on chronic airway remodeling produced by repetitive TLR3 agonist challenges, and compared their efficacy with that of two nonselective bromodomain and extraterminal (BET) protein inhibitors, JQ1 and RVX208. "
2.	Fibrosis (Cirrhosis) 01/01/2019 - "ZL0454 prevents epithelial mesenchymal transition, myofibroblast expansion, IgE sensitization, and fibrosis in airways of naive mice exposed to cat dander. " 01/01/2019 - "We observed that ZL0420 and ZL0454 more potently reduced polyinosinic:polycytidylic acid-induced weight loss and fibrosis as assessed by microcomputed tomography and second harmonic generation microscopy. "
3.	Weight Loss (Weight Reduction) 01/01/2019 - "We observed that ZL0420 and ZL0454 more potently reduced polyinosinic:polycytidylic acid-induced weight loss and fibrosis as assessed by microcomputed tomography and second harmonic generation microscopy. "
4.	Inflammation (Inflammations) 01/01/2019 - "We report a systems-level pharmacoproteomics in a standardized murine model of toll-like receptor TLR3-NFκB/RelA innate inflammation in the absence or presence of a highly selective BRD4 inhibitor (ZL0454) or nonselective bromodomain and extraterminal domain inhibitor (JQ1). "

Related Drugs and Biologics

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4.	Poly I-C
5.	Immunoglobulin E (IgE)