HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

AC1Q3QWB

disruptor of HOTAIR-EZH2 interaction

Also Known As:

N-((5,7-Dichloro-2,3-Dihydro-1-Benzofuran-2-Yl)Methyl)Propan-2-Amine

Networked: 4 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzofurans: 26
      - AC1Q3QWB: 4

Experts

1.	Li, Yansheng: 2 articles (01/2020 - 01/2019)
2.	Deng, Yan: 1 article (01/2020)
3.	Li, Kuanxun: 1 article (01/2020)
4.	Lv, Shigang: 1 article (01/2020)
5.	Shi, Jin: 1 article (01/2020)
6.	Wang, Xianggan: 1 article (01/2020)
7.	Wu, Miaojing: 1 article (01/2020)
8.	Ye, Minhua: 1 article (01/2020)
9.	Zhao, Hongyu: 1 article (01/2020)
10.	Zhu, Xingen: 1 article (01/2020)

Related Diseases

1.	Endometrial Neoplasms (Endometrial Cancer) 12/01/2023 - "Compound AC1Q3QWB upregulates CDKN1A and SOX17 by interrupting the HOTAIR-EZH2 interaction and enhances the efficacy of tazemetostat in endometrial cancer."
2.	Carcinogenesis 03/01/2023 - "The present study aimed to explore the effect of AC1Q3QWB (AQB) on colon carcinogenesis in vivo. "
3.	Colorectal Neoplasms (Colorectal Cancer) 03/01/2023 - "AC1Q3QWB inhibits colorectal cancer progression by modulating the immune response and balancing the structure of the intestinal microbiota."
4.	Neoplasms (Cancer) 01/01/2019 - "Herein, we identified a small-molecule compound AC1Q3QWB (AQB) as a selective and efficient disruptor of HOTAIR-EZH2 interaction, resulting in blocking of PRC2 recruitment and increasing tumor suppressors expression. " 01/01/2019 - "A Compound AC1Q3QWB Selectively Disrupts HOTAIR-Mediated Recruitment of PRC2 and Enhances Cancer Therapy of DZNep."
5.	Glioma (Gliomas) 01/01/2020 - "HOTAIR-EZH2 inhibitor AC1Q3QWB upregulates CWF19L1 and enhances cell cycle inhibition of CDK4/6 inhibitor palbociclib in glioma."

Related Drugs and Biologics

1.	tazemetostat
2.	palbociclib
3.	3-deazaneplanocin

Related Therapies and Procedures

1.	Therapeutics