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AH7614

FFA4 antagonist

Also Known As:

4-Methyl-N-9H-xanthen-9-yl-benzenesulfonamide

Networked: 4 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Nakamoto, Kazuo: 1 article (01/2022)
2.	Tokuyama, Shogo: 1 article (01/2022)
3.	Li, Wenyao: 1 article (01/2021)
4.	Pang, Yanmin: 1 article (01/2021)
5.	Sun, Haiyun: 1 article (01/2021)
6.	Zhao, Dan: 1 article (01/2021)
7.	Chu, Xiao: 1 article (02/2019)
8.	Gu, Yuting: 1 article (02/2019)
9.	He, Songbing: 1 article (02/2019)
10.	Jin, Min: 1 article (02/2019)

Related Diseases

1.	Inflammation (Inflammations) 01/01/2021 - "Moreover, AH7614 weakened the inhibitory effects of STG on inflammation and TAK1/NF‑κB pathway activity in LPS‑induced RAW264.7 cells. " 01/01/2021 - "Additionally, AH7614 reversed the inhibitory effects of STG on lung injury, inflammation, and TAK1/NF‑κB pathway activity in ALI. " 01/01/2022 - "In an ex vivo adipocyte culture study, DHA dose-dependently suppressed the lipopolysaccharide-induced inflammation in the adipocyte tissue of WT mice, which was reversed by pretreatment with AH7614, a GPR120/FFAR4 antagonist, but not GPR40 or peroxisome proliferator-activated receptor γ antagonist. "
2.	Lung Injury 01/01/2021 - "Additionally, AH7614 reversed the inhibitory effects of STG on lung injury, inflammation, and TAK1/NF‑κB pathway activity in ALI. "
3.	Neoplasms (Cancer) 02/01/2019 - "The functional importance of GPR120 in chemoresistance was further validated using epirubicin-treated tumor xenografts, in which we showed that blockade of GPR120 signaling with AH7614 or GPR120-siRNA significantly compromised chemoresistance. "
4.	Hyperglycemia 01/01/2023 - "Pretreatment with AH7614, a GPR120 antagonist, partially canceled the improvement of postprandial hyperglycemia induced by LA. "

Related Drugs and Biologics

1.	Peroxisome Proliferator-Activated Receptors (PPAR)
2.	Lipopolysaccharides
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