Type II Lattice Corneal Dystrophy

Also Known As:

Lattice Corneal Dystrophy, Type II; Corneal Dystrophy, Lattice Type II; Familial Amyloid Polyneuropathy Type Iv; Familial Amyloidosis, Finnish Type; Gelsolin-Related Amyloidosis; Kymenlaakso Syndrome; Lattice Corneal Dystrophy Type Ii; Lattice Corneal Dystrophy, Gelsolin Type

Networked: 39 relevant articles (0 outcomes, 4 trials/studies)

Disease Context: Research Results

Eye Diseases: 3522
- Corneal Diseases: 916
  - Hereditary Corneal Dystrophies: 820
    - Type II Lattice Corneal Dystrophy: 39
- Hereditary Eye Diseases: 18
  - Hereditary Corneal Dystrophies: 820
    - Type II Lattice Corneal Dystrophy: 39
Congenital, Hereditary, and Neonatal Diseases and Abnormalities: 933
- Inborn Genetic Diseases: 11939
Nervous System Diseases: 14178
- Neurodegenerative Diseases: 42472
  - Nervous System Heredodegenerative Disorders: 63
    - Familial Amyloid Neuropathies: 656
      - Type II Lattice Corneal Dystrophy: 39
- Neuromuscular Diseases: 2005
  - Peripheral Nervous System Diseases: 11383
    - Amyloid Neuropathies: 170
      - Familial Amyloid Neuropathies: 656
        Type II Lattice Corneal Dystrophy: 39
Nutritional and Metabolic Diseases: 15
- Metabolic Diseases: 10142
  - Proteostasis Deficiencies: 1400
    - Amyloidosis: 11630
      - Familial Amyloidosis: 393
        Familial Amyloid Neuropathies: 656
        Type II Lattice Corneal Dystrophy: 39
      - Amyloid Neuropathies: 170
        Familial Amyloid Neuropathies: 656
        Type II Lattice Corneal Dystrophy: 39
  - Inborn Errors Metabolism: 1162
    - Familial Amyloidosis: 393
      - Familial Amyloid Neuropathies: 656
        Type II Lattice Corneal Dystrophy: 39

Related Diseases

1.	Amyloidosis
2.	Amyloid Plaque
3.	Familial Mediterranean Fever (Periodic Disease)
4.	Type II Lattice Corneal Dystrophy
5.	Meretoja syndrome

Experts

1.	Gettemans, Jan: 2 articles (01/2019 - 12/2016)
2.	Larsson, Mårten: 2 articles (01/2019 - 08/2009)
3.	Robinson, Robert C: 2 articles (01/2019 - 08/2009)
4.	Alafaleq, Munirah: 1 article (09/2021)
5.	Borderie, Vincent: 1 article (09/2021)
6.	Boutboul, Sandrine: 1 article (09/2021)
7.	Knoeri, Juliette: 1 article (09/2021)
8.	Grimes, Jonathan M: 1 article (01/2019)
9.	Li, Wenfei: 1 article (01/2019)
10.	Ren, Weitong: 1 article (01/2019)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Type II Lattice Corneal Dystrophy:

1.	GelsolinIBA 12/01/2003 - "Gelsolin-related familial amyloidosis, Finnish type, in a Portuguese family: clinical and neurophysiological studies." 09/26/2000 - "Elucidating the mechanism of familial amyloidosis- Finnish type: NMR studies of human gelsolin domain 2." 01/01/2019 - "The role of gelsolin domain 3 in familial amyloidosis (Finnish type)." 08/18/2009 - "The G2 Ca-binding site is mutated in gelsolin from familial amyloidosis (Finnish-type) patients. " 02/27/2001 - "The disintegration of a molecule: the role of gelsolin in FAF, familial amyloidosis (Finnish type)."
2.	Amyloid (Amyloid Fibrils)IBA 06/26/1998 - "Cells of the neuronal lineage play a major role in the generation of amyloid precursor fragments in gelsolin-related amyloidosis." 09/01/1996 - "In vitro expression analysis shows that the secretory form of gelsolin is the sole source of amyloid in gelsolin-related amyloidosis." 07/01/1993 - "Homozygous familial amyloidosis, Finnish type: demonstration of glomerular gelsolin-derived amyloid and non-amyloid tubular gelsolin." 06/01/1990 - "Amyloid in familial amyloidosis, Finnish type, is antigenically and structurally related to gelsolin." 07/01/1991 - "Familial amyloidosis, Finnish type (FAF), is an autosomal dominant form of amyloidosis which is related to a point mutation in the gelsolin gene localized on chromosome 9. The mutation corresponds to codon 187 of the secreted form of gelsolin, and is expressed in the amyloid fibril at residue 15. "
3.	Proteins (Proteins, Gene)FDA Link 11/21/2018 - "Protein aggregation is a hallmark of several degenerative diseases, including Alzheimer's disease, Parkinson's disease and familial amyloidosis (Finnish type) (FAF). " 09/26/2000 - "Familial amyloidosis-Finnish type (FAF) results from a single mutation at residue 187 (D187N or D187Y) within domain 2 of the actin-regulating protein gelsolin. " 09/28/1999 - "Mutations D187N and D187Y in domain 2 of the actin-regulating protein gelsolin cause familial amyloidosis-Finnish type (FAF). " 11/29/1993 - "Familial amyloidosis, Finnish type is caused by a single base mutation in gelsolin, an actin filament severing and capping protein that is present in most tissues and in blood plasma. " 03/01/2000 - "Hereditary gelsolin-related amyloidosis (AGel amyloidosis) is a systemic disorder caused by a G654A or G654T mutation in the gene coding for gelsolin, an actin-modulating protein. "
4.	Amyloidogenic ProteinsIBA 06/01/1990 - "Immunohistochemical studies of six patients with familial amyloidosis, Finnish type, showed that their amyloid deposits did not react with polyclonal antibodies against the amyloid proteins of other, established forms of systemic or cerebral amyloidosis. " 02/28/1992 - "The amyloid protein in familial amyloidosis, Finnish type, is a 71 amino acid long fragment of the inner region of mutant Asp187----Asn gelsolin. " 03/30/1990 - "Amyloid protein in familial amyloidosis (Finnish type) is homologous to gelsolin, an actin-binding protein." 06/01/1990 - "These studies show that the amyloid protein in familial amyloidosis, Finnish type, is not related to previously identified forms of amyloid, including prealbumin (transthyretin) variants, but represents a novel amyloidogenic protein related to gelsolin, a plasma and cytoplasmic protein."
5.	Peptides (Polypeptides)IBA 09/04/1995 - "In the present study, we show for the first time that apoE, isolated from human plasma, increases fibril formation of synthetic peptides comprising the amyloidogenic sequences of gelsolin amyloid related to familial amyloidosis Finnish type, and amyloid A found in secondary amyloidosis and familial Mediterranean fever. " 09/01/1996 - "In familial amyloidosis of the Finnish type (FAF), or gelsolin-related amyloidosis, the amyloid subunit protein consists of gelsolin peptides of amino acids 173-243 with the disease causing substitution at Asp187. "
6.	Prealbumin (Transthyretin)IBA 06/01/1990 - "These studies show that the amyloid protein in familial amyloidosis, Finnish type, is not related to previously identified forms of amyloid, including prealbumin (transthyretin) variants, but represents a novel amyloidogenic protein related to gelsolin, a plasma and cytoplasmic protein."
7.	Apolipoproteins E (ApoE)IBA 09/04/1995 - "In the present study, we show for the first time that apoE, isolated from human plasma, increases fibril formation of synthetic peptides comprising the amyloidogenic sequences of gelsolin amyloid related to familial amyloidosis Finnish type, and amyloid A found in secondary amyloidosis and familial Mediterranean fever. "
8.	AntibodiesIBA 06/01/1990 - "Immunohistochemical studies of six patients with familial amyloidosis, Finnish type, showed that their amyloid deposits did not react with polyclonal antibodies against the amyloid proteins of other, established forms of systemic or cerebral amyloidosis. "
9.	Microfilament Proteins (Actin Binding Proteins)IBA 02/01/2002 - "Mutations in domain 2 (D2, residues 151-266) of the actin-binding protein gelsolin cause familial amyloidosis-Finnish type (FAF). " 03/30/1990 - "Amyloid protein in familial amyloidosis (Finnish type) is homologous to gelsolin, an actin-binding protein."
10.	Amino Acids FDA Link 02/28/1992 - "The amyloid protein in familial amyloidosis, Finnish type, is a 71 amino acid long fragment of the inner region of mutant Asp187----Asn gelsolin. " 09/01/1996 - "In familial amyloidosis of the Finnish type (FAF), or gelsolin-related amyloidosis, the amyloid subunit protein consists of gelsolin peptides of amino acids 173-243 with the disease causing substitution at Asp187. "

Therapies and Procedures

1.	Phacoemulsification 01/01/2009 - "We report a patient with lattice corneal dystrophy type II, also known as Meretoja syndrome or familial amyloidosis Finnish type, who developed a corneal melt 15 days after uneventful phacoemulsification. "
2.	Penetrating Keratoplasty 03/01/2015 - "To analyze the outcome of penetrating keratoplasty (PK) to the first eye for corneal amyloidosis in familial amyloidosis, Finnish type (FAF). " 03/01/2015 - "Penetrating keratoplasty for corneal amyloidosis in familial amyloidosis, Finnish type."
3.	Contact Lenses 09/01/2021 - "To describe the management and multimodal imaging of lattice corneal dystrophy type II (LCD-II) complicated by an infectious keratitis due to a bandage contact lens and to review current literature. "
4.	Bandages (Bandage) 09/01/2021 - "To describe the management and multimodal imaging of lattice corneal dystrophy type II (LCD-II) complicated by an infectious keratitis due to a bandage contact lens and to review current literature. "