scedosporiosis

Also Known As:

Lomentospora prolificans infection; Lomentospora prolificans infections; Scedosporium infection; Scedosporium prolificans infection; Scedosporium prolificans infections; pseudallescheriasis

Networked: 108 relevant articles (11 outcomes, 5 trials/studies)

Relationship Network

Disease Context: Research Results

Infections: 526564
- Bacterial Infections and Mycoses: 1
  - Mycoses: 11300
    - Invasive Fungal Infections: 2693
      - scedosporiosis: 108

Related Diseases

1.	Fusariosis
2.	Aspergillosis
3.	Infections
4.	Invasive Candidiasis
5.	Cystic Fibrosis (Mucoviscidosis)

Experts

1.	Guarro, Josep: 9 articles (01/2017 - 06/2003)
2.	Bouchara, Jean-Philippe: 6 articles (07/2021 - 12/2009)
3.	Capilla, Javier: 6 articles (01/2017 - 06/2003)
4.	Tintelnot, Kathrin: 5 articles (01/2019 - 05/2007)
5.	Pastor, F Javier: 5 articles (09/2010 - 06/2003)
6.	Godon, Charlotte: 4 articles (07/2021 - 12/2017)
7.	Slavin, M A: 4 articles (06/2020 - 02/2003)
8.	Ampawong, Sumate: 3 articles (01/2022 - 01/2019)
9.	Lackner, Michaela: 3 articles (12/2021 - 11/2014)
10.	Staerck, Cindy: 3 articles (07/2021 - 12/2017)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to scedosporiosis:

1.	Voriconazole (Vfend)FDA LinkGeneric 10/01/2023 - "At our centre, S. boydii is the main causative species of scedosporiosis; voriconazole could be the first-line treatment in Taiwan. " 02/01/2009 - "Voriconazole holds out the promise of an effective treatment for invasive Scedosporium infection." 05/01/2008 - "The efficacy of voriconazole in 107 patients with scedosporiosis was analyzed. " 12/01/2003 - "Efficacy of voriconazole in treatment of systemic scedosporiosis in neutropenic mice." 12/24/2021 - "Three and four items were established for scedosporiosis and lomentosporiosis, respectively, with a maximum achievable score of 3 due to the separation of different treatment options with the maximum point value of 3 for voriconazole-based treatment. "
2.	Terbinafine (Lamisil)FDA LinkGeneric 02/01/2003 - "Successful control of disseminated Scedosporium prolificans infection with a combination of voriconazole and terbinafine." 06/01/2020 - "Voriconazole plus terbinafine combination antifungal therapy for invasive Lomentospora prolificans infections: analysis of 41 patients from the FungiScope® registry 2008-2019." 06/01/2009 - "The aims of the present review were thus to gain a better understanding of scedosporiosis epidemiology and clinical features, and to review recent advances in multimodal management of these infections, including surgery, recovery and/or enhancement of immunity, and antifungal combinations, especially voriconazole plus terbinafine." 02/01/2003 - "Reported here is a patient who developed disseminated Scedosporium prolificans infection following bone marrow transplantation and who was successfully treated with a combination of voriconazole and terbinafine in addition to aggressive surgical debridement. " 11/01/2009 - "Despite several studies having demonstrated the efficacy of terbinafine against nondermatophytic infections including azole-resistant candidiasis, invasive aspergillosis, disseminated fusariosis and scedosporiosis, the role of TRB in the management of these infections remains greatly underappreciated. "
3.	AzolesIBA 09/01/2010 - "Experimental murine scedosporiosis: histopathology and azole treatment." 11/01/2009 - "Despite several studies having demonstrated the efficacy of terbinafine against nondermatophytic infections including azole-resistant candidiasis, invasive aspergillosis, disseminated fusariosis and scedosporiosis, the role of TRB in the management of these infections remains greatly underappreciated. "
4.	Amphotericin B (Amphotericin)FDA LinkGeneric 12/01/2004 - "A novel murine model of cerebral scedosporiosis: lack of efficacy of amphotericin B." 07/01/2003 - "Voriconazole was administered as primary therapy in a patient with Scedosporium infection and, in patients with Aspergillus infections, after persistence of positive culture despite a cumulative dose of 3 g of a lipid formulation of amphotericin B. " 07/01/2018 - "CNS pseudallescheriasis did not respond to multiple combinations of antifungal agents, including amphotericin B, isoconazole, itraconazole, and voriconazole. "
5.	olorofimIBA 01/01/2021 - "We studied the in vivo efficacy of a new fungicidal agent, olorofim (formerly F901318), against scedosporiosis and lomentosporiosis in neutropenic animals. " 01/01/2021 - "In Vivo Efficacy of Olorofim against Systemic Scedosporiosis and Lomentosporiosis." 01/01/2021 - "These results indicate olorofim to be a promising therapeutic agent for systemic scedosporiosis/lomentosporiosis, devastating emerging fungal infections that are difficult to treat with currently available antifungals." 01/01/2023 - "In conclusion, alexidine, amorolfine and olorofim were identified as promising compounds to be studied against scedosporiosis and lomentosporiosis."
6.	ProdrugsIBA 01/01/2020 - "We evaluated the in vitro activity of MGX and the efficacy of the prodrug fosmanogepix (APX001) in immunosuppressed murine models of hematogenously disseminated fusariosis and pulmonary scedosporiosis. "
7.	albaconazoleIBA 06/01/2003 - "Efficacy of albaconazole (UR-9825) in treatment of disseminated Scedosporium prolificans infection in rabbits."
8.	SiderophoresIBA 12/01/2009 - "Studies are initiated in order to determine the potential usefulness of these siderophores as diagnostic markers of scedosporiosis." 12/01/2022 - "Previously evaluated as a treatment target in mucormycosis, siderophores have recently emerged as new diagnostic targets for invasive aspergillosis and scedosporiosis. "
9.	Recombinant ProteinsIBA 12/01/2017 - "Scedosporium boydii CatA1 and SODC recombinant proteins, new tools for serodiagnosis of Scedosporium infection of patients with cystic fibrosis." 07/19/2021 - "Further studies are needed to confirm the role of this enzyme in the pathogenesis of Scedosporium infections, including the production of a recombinant protein and study of its protective effect against the infection in a mouse model of scedosporiosis."
10.	EnzymesIBA 07/19/2021 - "Further studies are needed to confirm the role of this enzyme in the pathogenesis of Scedosporium infections, including the production of a recombinant protein and study of its protective effect against the infection in a mouse model of scedosporiosis."

Therapies and Procedures

1.	Therapeutics 06/01/2011 - "The survival rates of patients with advanced HIV disease and invasive scedosporiosis can be improved by rapid diagnosis by biopsy and requires complex therapy with a combination of active antifungal drugs, surgery and supportive immune augmentation." 02/01/2018 - "The current literature on urinary tract scedosporiosis is further reviewed with emphasis on treatment options and limitations of current antifungal therapy." 01/01/2011 - "SCEDOSPORIUM INFECTION IN A PATIENT WITH ANTI-TNFα THERAPY." 01/01/2008 - "In conclusion, scedosporiosis, although extremely rare, represents a big problem for clinicians because of its aggressive clinical presentation and the lack of an effective therapy. " 06/01/2003 - "There are no effective therapeutics for treating invasive Scedosporium prolificans infections. "
2.	Transplantation 03/01/2015 - "One heart transplant recipient and two kidney transplant recipients developed fatal scedosporiosis following deceased donor transplantation from the same donor, a nearly-drowned victim of a suicide attempt. " 01/01/2005 - "Time elapsed from transplantation to Scedosporium infection in transplant recipients has increased in recent years (P=.002). " 12/01/2001 - "Three patients are currently alive 3, 6 and 7 years after transplantation, showing persistent scedosporium infection. " 06/01/1990 - "The epidemiology of pseudallescheriasis complicating transplantation: Nosocomial and community-acquired infection." 06/01/1990 - "The epidemiology of pseudallescheriasis complicating transplantation: nosocomial and community-acquired infection."
3.	Organ Transplantation 11/01/2023 - "Given the substantial risk for death associated with Scedosporium infection among solid-organ transplant recipients, safety protocols for organ transplantation from nearly drowned donors should be thoroughly revaluated and refined." 03/01/2015 - "Three fatal scedosporiosis cases developed after solid organ transplantation, probably transmitted from the nearly-drowned donor. " 06/01/2009 - "Risk factors for scedosporiosis were malignancy, 74/162 (45.7%), cystic fibrosis, 19/172 (11.7%), and solid organ transplantation 14/162 (8.6%). " 01/01/2016 - "We present a case of disseminated Scedosporium apiospermum infection occurring in the recipient of a combined kidney and liver transplantation whose organs were donated by a near-drowning victim and review the literature of scedosporiosis in solid organ transplantation."
4.	Lung Transplantation 08/01/2014 - "Scedosporiosis followed lung transplantation in 55%, and other organ transplants (multivisceral [18%]; and heart, liver, small intestine [9% each]) in 45%. " 01/01/2009 - "Colonized CF patients are at high risk for the development of disseminated scedosporiosis after lung transplantation. " 12/01/2001 - "Pulmonary scedosporium infection following lung transplantation." 05/23/2013 - "Successful prevention of scedosporiosis after lung transplantation in a cystic fibrosis patient by combined local and systemic triazole therapy."
5.	Kidney Transplantation 04/01/2023 - "Two recipients developed Scedosporiosis after kidney transplantation from the same donor. " 03/01/2018 - "Specifically, a high suspicion index is necessary, considering Scedosporium infection among the differential diagnosis of invasive fungal diseases in renal transplantation patients. " 10/01/2004 - "We report a case of a 50-year-old Caucasian male with lymphocutaneous and presumed pulmonary Scedosporium infection 4 years after renal transplantation that was successfully treated with voriconazole and discontinuation of immunosuppression. "