protothecosis

12/01/2023 - "Intralesional amphotericin B in a cat with cutaneous protothecosis."
08/01/2012 - "The activity of amphotericin B against Prototheca spp. validates its potential use as a therapeutic agent against bovine protothecosis. "
03/01/2012 - "Serial MRI and CSF analysis in a dog treated with intrathecal amphotericin B for protothecosis."
08/01/2008 - "All 4 cases of disseminated protothecosis died despite therapy with amphotericin B. "
11/01/1997 - "Cutaneous protothecosis in a patient with AIDS and a severe functional neutrophil defect: successful therapy with amphotericin B."

06/22/2023 - "Correction to: Cutaneous protothecosis in a dog successfully treated with oral itraconazole in pulse dosing."
02/21/2023 - "Cutaneous protothecosis in a dog successfully treated with oral itraconazole in pulse dosing."
01/01/2018 - "This case of protothecosis was recorded in Kyushu, Japan, and oral treatment with itraconazole 200 mg/day for 2 months was effective. "
01/01/2001 - "A human case of protothecosis successfully treated with itraconazole."
06/01/1990 - "[Cutaneous protothecosis treated with itraconazole]."

09/01/1983 - "Successful ketoconazole treatment of protothecosis with ketoconazole-associated hepatotoxicity."
11/01/1996 - "Surgical excision, oral ketoconazole, intravenous amphotericin B alone or in combination with oral tetracycline have been reported to be effective in the management of protothecosis. "
08/01/1985 - "The protothecosis failed to respond to ketoconazole but resolved with combined amphotericin B and tetracycline hydrochloride therapy."

11/01/1996 - "We report a case of cutaneous protothecosis treated successfully with oral fluconazole. "
11/01/1996 - "Fluconazole appears to be an effective alternative to conventional drugs for the treatment of cutaneous protothecosis. "
06/01/2000 - "The first case of Protothecosis zopfii in human being was reported and successfully treated with local infiltration of Diflucan (fluconazole) 3 ml (2 mg/ml)/week x 4."
11/01/1996 - "We report a 55-year-old immunocompetent woman with cutaneous protothecosis which developed at the site of intralesional triamcinolone acetonide injection, who was successfully treated with oral fluconazole."
11/01/1996 - "Successful treatment with fluconazole of protothecosis developing at the site of an intralesional corticosteroid injection."

11/01/1996 - "Surgical excision, oral ketoconazole, intravenous amphotericin B alone or in combination with oral tetracycline have been reported to be effective in the management of protothecosis. "
08/01/1985 - "The protothecosis failed to respond to ketoconazole but resolved with combined amphotericin B and tetracycline hydrochloride therapy."

08/01/2020 - "RVZ was more potent than the other azoles against Protheca species and has considerable potential for use as a therapeutic agent for human and animal protothecosis."
09/03/2021 - "Although Prototheca, like fungi, has ergosterol in the cell membrane, efficacy of the antifungal azoles in the treatment of protothecosis is controversial. "
09/03/2021 - "An increasing number of human and animal cases of Prototheca infection (protothecosis) are reported, and antifungal azoles, which inhibit sterol 14α-demethylase (CYP51/ERG11) involved in ergosterol biosynthesis, have empirically been used for the treatment of protothecosis. "

09/03/2021 - "Although Prototheca, like fungi, has ergosterol in the cell membrane, efficacy of the antifungal azoles in the treatment of protothecosis is controversial. "
09/03/2021 - "An increasing number of human and animal cases of Prototheca infection (protothecosis) are reported, and antifungal azoles, which inhibit sterol 14α-demethylase (CYP51/ERG11) involved in ergosterol biosynthesis, have empirically been used for the treatment of protothecosis. "

01/01/1983 - "It is likely that this antibiotic could be effective in the treatment of protothecosis in man."

01/01/2013 - "Comprehensive characterization of Prototheca rDNA may provide valuable insights into diagnosis and epidemiology of protothecosis, as well as evolution and taxonomy of Prototheca and related organisms. "
12/01/2009 - "Molecular identification using a conserved 18S rDNA gene sequence determined that the strain belonged to genotype 2. This report describes success on treatment of canine protothecosis, diagnosed based on clinical, cytological, microbiological, scanning electron microscopy and genotypical findings."
10/01/2017 - "Here, we describe a first case of protothecosis in a carp (Cyprinus carpio), which is at the same time the first case of protothecosis in a fish, confirmed by phenotype- and molecular-based methods, including PCR sequencing of the rDNA cluster and protein profiling using matrix-assisted laser desorption ionization time-of-flight mass spectrometry."
04/01/2018 - "In this study, six strains of Prototheca isolated in China from human patients diagnosed as protothecosis and cows with mastitis were characterized by polymerase chain reaction (PCR) and nucleotide sequencing of the ribosomal RNA gene (rDNA) and by matrix-assisted laser desorption/ionization time of flight mass spectrometry (MALDI-TOF MS). "

01/01/2017 - "Histology showed spherical spore-like bodies with internal morula-like septation, which were positive for periodic-acid-Schiff (PAS) staining, consistent with cutaneous protothecosis. "
03/01/2001 - "Immunohistochemistry (IHC) of bovine cytokeratin combined with periodic acid-Schiff (PAS) was applied to study the pathogenesis, localization and distribution of Prototheca zopfii in bovine mammary protothecosis. "
01/01/2001 - "Histopathological examination showed typical protothecosis with numerous mulberry-like sporangia positive for periodic acid-Schiff stain. "

01/01/2001 - "Only 12 cases of protothecosis treated with ITCZ have been reported in the literature; 8 of these cases were cured with ITCZ therapy alone. "
01/01/2016 - "Systemic therapy seems to be ineffective for skin nodules, at least in chronic cases of canine cutaneous protothecosis. "
11/01/2014 - "There are different treatment regimens described but there are no clear published guidelines of specific therapy of protothecosis. "
02/01/2012 - "Few available therapies and the rapid spread of resistant strains worldwide support the need for novel drugs against protothecosis. "
09/01/1990 - "Visceral protothecosis mimicking sclerosing cholangitis in an immunocompetent host: successful antifungal therapy."

08/01/2015 - "We reviewed previous cases of protothecosis involving solid organ transplant recipients in the literature and discussed the value of newer microbiology platforms, i.e., matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF), to achieve early diagnosis and impact outcomes."
10/01/2017 - "Here, we describe a first case of protothecosis in a carp (Cyprinus carpio), which is at the same time the first case of protothecosis in a fish, confirmed by phenotype- and molecular-based methods, including PCR sequencing of the rDNA cluster and protein profiling using matrix-assisted laser desorption ionization time-of-flight mass spectrometry."
04/01/2018 - "In this study, six strains of Prototheca isolated in China from human patients diagnosed as protothecosis and cows with mastitis were characterized by polymerase chain reaction (PCR) and nucleotide sequencing of the ribosomal RNA gene (rDNA) and by matrix-assisted laser desorption/ionization time of flight mass spectrometry (MALDI-TOF MS). "

07/01/1997 - "In this immunohistochemical study, the distribution of the cellular inflammatory infiltrate associated with cutaneous canine protothecosis (Prototheca wickerhamii) was evaluated by consecutive biopsies taken before, during and after treatment. "

10/01/2018 - "Disseminated Protothecosis Caused by Prototheca zopfii in a Liver Transplant Recipient."
09/01/2014 - "Pulmonary Protothecosis in a Pediatric Liver Transplant Patient."
08/01/2008 - "Protothecosis after liver transplantation."
09/01/2014 - "We report the first pediatric liver transplant recipient with pulmonary protothecosis, detected during an episode of Pneumocystis jirovecii pneumonia, and we conducted a review of the available literature. "
08/01/2008 - "We report a liver transplant recipient with disseminated protothecosis and review the literature on this unusual opportunistic infection in transplant recipients. "

06/01/2014 - "Tumor necrosis factor-alpha inhibitors and contamination of central venous catheters may contribute to development of protothecosis. "