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QW-296

microtubule destabilizer

Also Known As:

(2-(4-hydroxy-1H-indol-3-yl)-1H-imidazol-4-yl)(3,4,5-trimethoxyphenyl)methanone

Networked: 1 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Imidazoles: 150
      - QW-296: 1
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - QW-296: 1

Experts

1.	Chen, Hao: 1 article (01/2019)
2.	Dong, Yuxiang: 1 article (01/2019)
3.	Guo, Dawei: 1 article (01/2019)
4.	Li, Wei: 1 article (01/2019)
5.	Mahato, Ram I: 1 article (01/2019)
6.	Miller, Duane D: 1 article (01/2019)
7.	Yang, Ruinan: 1 article (01/2019)

Related Diseases

1.	Prostatic Neoplasms (Prostate Cancer) 01/01/2019 - "We have designed a novel microtubule destabilizer (2-(4-hydroxy-1H-indol-3-yl)-1H-imidazol-4-yl)(3,4,5-trimethoxyphenyl)methanone (QW-296) and combined it with a newly synthesized hedgehog (Hh) signaling pathway inhibitor 2-chloro-N 1-[4-chloro-3-(2-pyridinyl)phenyl]-N 4,N 4- bis(2-pyridinylmethyl)-1,4-benzenedicarboxamide (MDB5) to treat taxane-resistant (TXR) prostate cancer. " 01/01/2019 - "The overall findings suggest that combination therapy with QW-296 and MDB5 has great clinical potential to treat TXR prostate cancer, and copolymer mPEG-p(TMC-MBC) could serve as an effective delivery vehicle to boost therapeutic efficacy in vivo."
2.	Neoplasms (Cancer) 01/01/2019 - "The combination of QW-296 and MDB5 exhibited stronger anticancer activity toward DU145-TXR and PC3-TXR cells and suppressed tumor colony formation when compared with single-drug treatment. " 01/01/2019 - "There was maximum tumor growth inhibition in the group treated with the combination therapy of QW-296 and MDB5 in micelles compared with their monotherapies or combination therapy formulated in cosolvent. "

Related Drugs and Biologics

1.	monomethoxypolyethylene glycol (MPEG)
2.	MDB5
3.	Micelles
4.	taxane

Related Therapies and Procedures

1.	Therapeutics