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CORM-401

an oxidant-sensitive CO-releasing molecule

Also Known As:

Tetracarbonyl(N-(dithiocarboxy-kappaS,kappaS')-N-methylglycine)manganate

Networked: 7 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Peptoids: 93
    - N-substituted Glycines
      - CORM-401: 7
- Amino Acids: 30675
  - Glycine: 5151
    - N-substituted Glycines
      - CORM-401: 7

Experts

1.	Motterlini, Roberto: 2 articles (11/2018 - 10/2018)
2.	Cepinskas, Gediminas: 2 articles (01/2018 - 05/2017)
3.	Braud, Laura: 1 article (11/2018)
4.	Czibik, Gabor: 1 article (11/2018)
5.	Derumeaux, Geneviève: 1 article (11/2018)
6.	Foresti, Roberta: 1 article (11/2018)
7.	Kitagishi, Hiroaki: 1 article (11/2018)
8.	Manin, Sylvie: 1 article (11/2018)
9.	Muchova, Lucie: 1 article (11/2018)
10.	Pini, Maria: 1 article (11/2018)

Related Diseases

1.	Body Weight (Weight, Body) 11/15/2018 - "Here, we show that oral administration of CORM-401 to obese mice fed a high-fat diet (HFD) resulted in a significant reduction in body weight gain, accompanied by a marked improvement in glucose homeostasis. " 01/01/2023 - "The manganese-based CORM-401 has been recently reported to exert beneficial effects in obese animals by reducing body weight gain, improving glucose metabolism and reprogramming adipose tissue towards a healthy phenotype. "
2.	Periodontal Diseases (Periodontal Disease) 02/01/2023 - "intermedia LPS independently of PPAR-γ, JNK, p38 and STAT1/3. The modulation of host inflammatory response by CORM-401 might be of help in the therapy of periodontal disease." 02/01/2023 - "This study was performed to investigate the influence of CORM-401 on the generation of nitric oxide (NO) in murine macrophage cells activated with lipopolysaccharide (LPS) derived from Prevotella intermedia, a pathogen associated with periodontal disease. "
3.	Endotoxemia 05/01/2017 - "We investigated modulation of PMN-endothelial cell adhesive interactions by water-soluble CORM-401 using an experimental model of endotoxemia in vitro. "
4.	Weight Gain 11/15/2018 - "Our findings indicate that the transient uncoupling activity of CO elicited by repetitive administration of CORM-401 is associated with lower weight gain and increased insulin sensitivity during HFD. "
5.	Reperfusion Injury 01/01/2018 - "CORM-401 Reduces Ischemia Reperfusion Injury in an Ex Vivo Renal Porcine Model of the Donation After Circulatory Death." 01/01/2018 - "We report the ability of this anti-inflammatory CORM-401 to reduce ischemia reperfusion injury associated with prolonged cold storage of renal allografts obtained from donation after circulatory death in a porcine model of transplantation. "

Related Drugs and Biologics

1.	Glucose (Dextrose)
2.	Nitric Oxide (Nitrogen Monoxide)
3.	Lipopolysaccharides
4.	Peroxisome Proliferator-Activated Receptors (PPAR)
5.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
6.	Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)
7.	Solutions
8.	Manganese
9.	Cysteine (L-Cysteine)
10.	PAPA NONOate

Related Therapies and Procedures

1.	Oral Administration
2.	Transplantation
3.	Therapeutics