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secosterol-B

a cholesterol autoxidation product

Also Known As:

3beta-hydroxy-5beta-hydroxy-B-norcholestane-6betacarboxaldehyde

Networked: 5 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Polycyclic Compounds: 6
- Fused-Ring Compounds
  - Steroids: 70059
    - Cholestanes
      - Sterols: 2245
        Cholesterol: 67133
        secosterol-B: 5
      - Cholestenes
        Cholesterol: 67133
        secosterol-B: 5
Lipids: 114793
- Membrane Lipids: 1591
  - Sterols: 2245
    - Cholesterol: 67133
      - secosterol-B: 5

Experts

1.	Miyoshi, Noriyuki: 4 articles (03/2018 - 01/2011)
2.	Ohshima, Hiroshi: 3 articles (01/2012 - 01/2011)
3.	Tomono, Susumu: 3 articles (01/2012 - 01/2011)
4.	Higashi, Tatsuya: 2 articles (09/2011 - 01/2011)
5.	Canonico, Barbara: 1 article (01/2019)
6.	Cesarini, Erica: 1 article (01/2019)
7.	Crinelli, Rita: 1 article (01/2019)
8.	Guidi, Loretta: 1 article (01/2019)
9.	Iuliano, Luigi: 1 article (01/2019)
10.	Luchetti, Francesca: 1 article (01/2019)

Related Diseases

1.	Atherosclerotic Plaque (Atheroma) 01/01/2019 - "The present study shows that secosterol-B (SEC-B), 3β-hydroxy-5β-hydroxy-B-norcholestane-6βcarboxaldehyde, a cholesterol autoxidation product recently identified in the atherosclerotic plaque, is able to induce ER stress in HUVEC cells, as revealed by significant expansion and change of structure. " 03/01/2018 - "Elevated levels of cholesterol aldehyde, 3β-hydroxy-5-oxo-5,6-secocholestan-6-al (secosterol-A, also called 5,6-secosterol), and its aldolization product (secosterol-B) have been detected in human atherosclerotic plaques and tissues samples of brains affected by neurodegeneration, such as Alzheimer's disease and Lewy body dementia suggesting that increased formation of these compounds may be associated with inflammation-related diseases. "
2.	Atherosclerosis 01/01/2011 - "3β-Hydroxy-5-oxo-5,6-secocholestan-6-al (secosterol-A) and its aldolization product 3β-hydroxy-5β-hydroxy-B-norcholestane-6β-carboxaldehyde (secosterol-B) were recently detected in human atherosclerotic tissues and brain specimens, and they may play pivotal roles in the pathogenesis of atherosclerosis and neurodegenerative diseases. " 01/01/2012 - "The cholesterol ozonolysis products secosterol-A and its aldolization product secosterol-B were recently detected in human atherosclerotic tissues and brain specimens, and have been postulated to play pivotal roles in the pathogenesis of atherosclerosis and neurodegenerative diseases. " 09/15/2011 - "Cholesterol ozonolysis products, 3β-hydroxy-5-oxo-5,6-secocholestan-6-al (secosterol-A) and its aldolization product 3β-hydroxy-5β-hydroxy-B-norcholestane-6β-carboxaldehyde (secosterol-B) have been found in atherosclerosis plaques and the brain tissues of Alzheimer's disease patients, implicating them in the pathogenesis of cardiovascular and neurodegenerative diseases. "
3.	Neurodegenerative Diseases (Neurodegenerative Disease) 01/01/2011 - "3β-Hydroxy-5-oxo-5,6-secocholestan-6-al (secosterol-A) and its aldolization product 3β-hydroxy-5β-hydroxy-B-norcholestane-6β-carboxaldehyde (secosterol-B) were recently detected in human atherosclerotic tissues and brain specimens, and they may play pivotal roles in the pathogenesis of atherosclerosis and neurodegenerative diseases. " 01/01/2012 - "The cholesterol ozonolysis products secosterol-A and its aldolization product secosterol-B were recently detected in human atherosclerotic tissues and brain specimens, and have been postulated to play pivotal roles in the pathogenesis of atherosclerosis and neurodegenerative diseases. " 09/15/2011 - "Cholesterol ozonolysis products, 3β-hydroxy-5-oxo-5,6-secocholestan-6-al (secosterol-A) and its aldolization product 3β-hydroxy-5β-hydroxy-B-norcholestane-6β-carboxaldehyde (secosterol-B) have been found in atherosclerosis plaques and the brain tissues of Alzheimer's disease patients, implicating them in the pathogenesis of cardiovascular and neurodegenerative diseases. "
4.	Alzheimer Disease (Alzheimer's Disease) 09/15/2011 - "Cholesterol ozonolysis products, 3β-hydroxy-5-oxo-5,6-secocholestan-6-al (secosterol-A) and its aldolization product 3β-hydroxy-5β-hydroxy-B-norcholestane-6β-carboxaldehyde (secosterol-B) have been found in atherosclerosis plaques and the brain tissues of Alzheimer's disease patients, implicating them in the pathogenesis of cardiovascular and neurodegenerative diseases. " 03/01/2018 - "Elevated levels of cholesterol aldehyde, 3β-hydroxy-5-oxo-5,6-secocholestan-6-al (secosterol-A, also called 5,6-secosterol), and its aldolization product (secosterol-B) have been detected in human atherosclerotic plaques and tissues samples of brains affected by neurodegeneration, such as Alzheimer's disease and Lewy body dementia suggesting that increased formation of these compounds may be associated with inflammation-related diseases. "
5.	Lewy Body Disease (Lewy Body Dementia) 03/01/2018 - "Elevated levels of cholesterol aldehyde, 3β-hydroxy-5-oxo-5,6-secocholestan-6-al (secosterol-A, also called 5,6-secosterol), and its aldolization product (secosterol-B) have been detected in human atherosclerotic plaques and tissues samples of brains affected by neurodegeneration, such as Alzheimer's disease and Lewy body dementia suggesting that increased formation of these compounds may be associated with inflammation-related diseases. "

Related Drugs and Biologics

1.	Cholesterol
2.	Aldehydes
3.	Proteins (Proteins, Gene)