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tambulin

a major active compound of a methanolic extract of fruits of Zanthoxylum armatum

Also Known As:

3,5-dihydroxy-7,8-dimethoxy-2-(4-methoxyphenyl) chromen-4-one

Networked: 3 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - Benzopyrans: 195
      - tambulin: 3
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzopyrans: 195
      - tambulin: 3

Experts

1.	Ahmad, Ateeque: 2 articles (01/2019 - 05/2017)
2.	Nooreen, Zulfa: 2 articles (01/2019 - 05/2017)
3.	Liu, Yuzhen: 1 article (01/2020)
4.	Wang, Wuming: 1 article (01/2020)
5.	Zhao, Long: 1 article (01/2020)
6.	Bhatta, Rabi S: 1 article (01/2019)
7.	Mishra, Anjali: 1 article (01/2019)
8.	Pandey, Rakesh: 1 article (01/2019)
9.	Pandey, Taruna: 1 article (01/2019)
10.	Sammi, Shreesh Raj: 1 article (01/2019)

Related Diseases

1.	Parkinson Disease (Parkinson's Disease) 01/01/2019 - "Our studies present tambulin as a potential molecule for its properties against ageing and Parkinson's disease. "
2.	Skin Neoplasms (Skin Cancer) 05/01/2017 - "Tambulin which was also found in maximum amount (0.125%) in fruits revealed significant antiproliferative activity (IC50 37.96±0.36 to 48.7±0.21μg/mL) against breast, liver, colon and skin cancer cell lines corroborated by resilient binding interaction with SDH (-6.76Kcal/mol) and inhibition constant (Ki: 11.02μM). "
3.	Neoplasms (Cancer) 01/01/2020 - "Results showed that tambulin inhibited the proliferation of H226 and H520 cells in a dose-dependent manner and inhibited the growth of CDX tumors. " 01/01/2020 - "Mechanistically, tambulin downregulates HDAC1, which in turn regulates the Bcl-2/caspase signaling pathway and promotes cancer cell apoptosis." 01/01/2020 - "In support of this, immunohistochemical analysis of CDX tumors from mice treated with tambulin showed increased expression of cleaved caspase-3 and Bax, while the expression of HDAC1 and Bcl-2 were decreased. "
4.	Squamous Cell Carcinoma (Epidermoid Carcinoma) 01/01/2020 - "Tambulin Targets Histone Deacetylase 1 Inhibiting Cell Growth and Inducing Apoptosis in Human Lung Squamous Cell Carcinoma."

Related Drugs and Biologics

1.	Histone Deacetylase 1
2.	Caspase 3 (Caspase-3)
3.	Caspases