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AZD3342

No structural information available. 403 D synthetic inhibitor of MMP-8, MMP-9, and MMP-12.

Networked: 1 relevant articles (1 outcomes, 1 trials/studies)

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Bio-Agent Context: Research Results

Organic Chemicals: 133
- AZD3342: 1

Experts

1.	Ball, Imogen A: 1 article (01/2018)
2.	Bowen, Joanne M: 1 article (01/2018)
3.	Gibson, Rachel J: 1 article (01/2018)
4.	Shirren, Joseph: 1 article (01/2018)
5.	Wanner, Kiara: 1 article (01/2018)
6.	Wardill, Hannah R: 1 article (01/2018)
7.	Wignall, Anthony: 1 article (01/2018)
8.	Williams, Nicole: 1 article (01/2018)
9.	van Sebille, Ysabella Z A: 1 article (01/2018)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2018 - "AZD3342 alone suppressed tumor growth (p = 0.003 vs. vehicle) but did not enhance the efficacy of MTX. " 01/01/2018 - "This study showed partial efficacy of AZD3342 in reducing tumor growth and delaying the onset of severe diarrhea caused by MTX in rats. " 01/01/2018 - "The aim of this study was to determine the efficacy of an MMP-9/12 inhibitor, AZD3342, on tumor growth and GI toxicity in a rat model. " 01/01/2018 - "Female tumor-bearing Dark Agouti rats (n = 90) were divided into 4 groups: vehicle control; methotrexate (MTX); AZD3342, and MTX + AZD3342. "
2.	Diarrhea 01/01/2018 - "AZD3342 delayed the onset of severe diarrhea by 1 day (vs. MTX) but was unable to improve the overall severity of diarrhea. " 01/01/2018 - "This study showed partial efficacy of AZD3342 in reducing tumor growth and delaying the onset of severe diarrhea caused by MTX in rats. "

Related Drugs and Biologics

1.	Matrix Metalloproteinases (MMPs)
2.	Methotrexate (Mexate)