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MH-76 compound

an alpha1-adrenoceptor agonist with vasorelaxant properties

Also Known As:

1-((2,6-dimethylphenoxy)propyl)-4-(2-methoxyphenyl)piperazine hydrochloride; MH-76

Networked: 4 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Piperazines: 26
    - MH-76 compound: 4

Experts

1.	Kotańska, Magdalena: 3 articles (05/2021 - 01/2019)
2.	Kubacka, Monika: 3 articles (05/2021 - 01/2019)
3.	Marona, Henryk: 3 articles (05/2021 - 01/2019)
4.	Mogilski, Szczepan: 3 articles (05/2021 - 01/2019)
5.	Nowak, Barbara: 2 articles (05/2021 - 01/2019)
6.	Szafarz, Małgorzata: 2 articles (05/2021 - 01/2019)
7.	Zadrożna, Monika: 2 articles (05/2021 - 01/2019)
8.	Filipek, Barbara: 2 articles (01/2019 - 01/2019)
9.	Bednarski, Marek: 1 article (05/2021)
10.	Jawień, Wojciech: 1 article (05/2021)

Related Diseases

1.	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/01/2019 - "α1-adrenoceptor blockade, endothelial protection, TNF-α suppressing and antioxidant activity together with favorable pharmacokinetic parameters determines high efficacy of MH-76, leading to the effective improvement of hemodynamic and metabolic disturbances in metabolic syndrome. " 01/01/2019 - "We investigated if MH-76 and MH-79, non-quinazoline α1-adrenoceptor antagonists with an additional ability to stimulate NO/cGMP/K+ pathway, ameliorates metabolic syndrome in fructose-fed rats. " 11/03/2023 - "Manifestations of Liver Impairment and the Effects of MH-76, a Non-Quinazoline α1-Adrenoceptor Antagonist, and Prazosin on Liver Tissue in Fructose-Induced Metabolic Syndrome."
2.	Hypertrophy 01/01/2019 - "This study showed that the administration of MH-79 and, to a lesser extent, MH-76 decreased elevated systolic blood pressure and heart rate, reduced heart and kidney hypertrophy, and reversed the histopathological alterations of the heart, kidney, and vessels in DOCA-salt hypertensive rats. "
3.	Insulin Resistance 01/01/2019 - "Moreover, MH-76 reduced insulin resistance and decreased TNF-α concentration and lipid peroxidation in adipose tissue. " 11/03/2023 - "MH-76 (1-[3-(2,6-dimethylphenoxy)propyl]-4-(2-methoxyphenyl)piperazine hydrochloride)) is a non-quinazoline α1-adrenoceptor antagonist which, in fructose-fed rats, exerted anti-inflammatory, antihypertensive properties and reduced insulin resistance and visceral adiposity. " 05/18/2021 - "MH-76 (1-[3-(2,6-dimethylphenoxy)propyl]-4-(2-methoxyphenyl)piperazine hydrochloride)) is a non-quinazoline α1-adrenoceptor antagonist which, in fructose-fed rats, exerted antihypertensive effect, and, contrary to prazosin, reduced insulin resistance and abdominal adiposity. "
4.	Inflammation (Inflammations) 05/18/2021 - "MH-76, a Novel Non-Quinazoline α1-Adrenoceptor Antagonist, but Not Prazosin Reduces Inflammation and Improves Insulin Signaling in Adipose Tissue of Fructose-Fed Rats."
5.	Hypertension (High Blood Pressure) 01/01/2019 - "We investigated the therapeutic effect of MH-76 and MH-79, which are non-quinazoline α1-adrenoceptor antagonists with an additional ability to stimulate the nitric oxide (NO)/cyclic guanosine monophosphate (cGMP)/K + pathway, on deoxycorticosterone acetate (DOCA)-salt induced hypertension in rats. "

Related Drugs and Biologics

1.	MH-79 compound
2.	Quinazolines
3.	Fructose
4.	Antioxidants
5.	Desoxycorticosterone Acetate (DOCA)
6.	Salts
7.	Adrenergic Receptors (Adrenergic Receptor)
8.	Prazosin (Minipress)
9.	Antihypertensive Agents (Antihypertensives)
10.	Piperazine