WF-210 compound

a procaspase-3 activating compound derived from procaspase activating compound-1 (PAC-1 compound)

Also Known As:

N'-(4-((2-(benzo(d)(1,3)dioxol-5-ylmethyl)thiazol-4-yl)methoxy)-2-hydroxybenzylidene)-2-(4-((3-(4-((4-fluorophenoxy)methyl)phenyl)-1,2,4-oxadiazol-5-yl)methyl)piperazin-1-yl)acetohydrazide; WF-210

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Benzylidene Compounds: 10
        WF-210 compound: 2
- Hydrazines: 379
  - WF-210 compound: 2
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds

Experts

1.	Gong, Ping: 2 articles (02/2018 - 12/2014)
2.	Li, Yi: 2 articles (02/2018 - 12/2014)
3.	Wang, Fangyang: 2 articles (02/2018 - 12/2014)
4.	Wang, Lihui: 2 articles (02/2018 - 12/2014)
5.	Wu, Chunfu: 2 articles (02/2018 - 12/2014)
6.	Yang, Jingyu: 2 articles (02/2018 - 12/2014)
7.	Cao, Qi: 1 article (02/2018)
8.	Wang, Nannan: 1 article (02/2018)
9.	Wang, Yating: 1 article (02/2018)
10.	Chen, Kang: 1 article (12/2014)

Related Diseases

1.	Neoplasms (Cancer) 02/15/2018 - "The aim of this study was to extend current knowledge about the mechanisms of PAC-1 and WF-210, particularly about their effects on tumor angiogenesis. " 02/15/2018 - "When given to mice bearing subcutaneous or orthotopic xenograft, PAC-1 and WF-210 inhibited the tumor growth and tumor angiogenesis. " 12/01/2014 - "WF-210 was more cytotoxic than PAC-1 to human cancer cells, but less cytotoxic to normal cells. " 02/15/2018 - "Procaspase Activating Compound-1 (PAC-1) and its derivative WF-210 induce apoptosis in cancer cells by activating procaspase-3 to caspase-3. " 12/01/2014 - "The favorable antitumor activity and acceptable toxicity profile of WF-210 provide a strong rationale for its clinical evaluation in the treatment of tumors with high procaspase-3 expression."
2.	Weight Loss (Weight Reduction) 12/01/2014 - "Finally, WF-210 was superior to PAC-1 in retarding the in vivo growth of breast, liver and gallbladder xenograft tumors which overexpress procaspase-3, and induced no substantial weight loss or neurotoxicity. "

Related Drugs and Biologics

1.	Caspase 3 (Caspase-3)