Z-505 hydrochloride

a ghrelin receptor agonist

Also Known As:

(2R)-2-(2-amino-2-methylpropinoylamino)-N-(2-oxo-8-(2-oxo-pyrrolidin-1-yl)-1-(3-thienylmethyl)((3R*)-1-3,4-trihydroquinol-3yl))-4-methylpentanamide hydrochloride

Networked: 2 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amides: 2428
  - Z-505 hydrochloride: 2
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrrolidines: 115
    - Z-505 hydrochloride: 2

Experts

1.	Ohira, Yuta: 2 articles (01/2018 - 09/2017)
2.	Shiomi, Yoshihiro: 2 articles (01/2018 - 09/2017)
3.	Takei, Mineo: 2 articles (01/2018 - 09/2017)
4.	Tanaka, Takao: 2 articles (01/2018 - 09/2017)
5.	Yoshimura, Makoto: 2 articles (01/2018 - 09/2017)
6.	Ozaki, Tomoko: 1 article (01/2018)

Related Diseases

1.	Anorexia 01/05/2018 - "Z-505 hydrochloride ameliorates chemotherapy-induced anorexia in rodents via activation of the ghrelin receptor, GHSR1a." 01/05/2018 - "To investigate the potential of ghrelin receptor agonists, synthetic small-molecule compounds, as preventive therapies for chemotherapy-induced anorexia, we studied the effects of Z-505 hydrochloride (Z-505), a new oral growth hormone secretagogue receptor 1a (GHSR1a) agonist, in cisplatin- and 5-fluorouracil (5-FU)-induced anorexia animal models. "
2.	Neoplasms (Cancer) 09/15/2017 - "We investigated the anti-cachexia effects of Z-505 hydrochloride (Z-505), a new oral growth hormone secretagogue receptor 1a (GHSR1a) agonist, using a mouse model of cancer cachexia. " 09/15/2017 - "Z-505 hydrochloride, an orally active ghrelin agonist, attenuates the progression of cancer cachexia via anabolic hormones in Colon 26 tumor-bearing mice."
3.	Cachexia 09/15/2017 - "We investigated the anti-cachexia effects of Z-505 hydrochloride (Z-505), a new oral growth hormone secretagogue receptor 1a (GHSR1a) agonist, using a mouse model of cancer cachexia. " 09/15/2017 - "Z-505 hydrochloride, an orally active ghrelin agonist, attenuates the progression of cancer cachexia via anabolic hormones in Colon 26 tumor-bearing mice."

Related Drugs and Biologics

1.	Ghrelin Receptors
2.	Ghrelin
3.	Hormones (Hormone)
4.	Fluorouracil (Carac)
5.	Cisplatin (Platino)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Therapeutics