MP0250

a recombinant polypeptide consisting of anti-vascular endothelial growth factor-A (VEGF-A), one anti-hepatocyte growth factor (HGF), and two anti-human serum albumin (HSA) DARPin domains

Networked: 4 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Fiedler, Ulrike: 4 articles (10/2021 - 11/2017)
2.	Stumpp, Michael T: 3 articles (10/2021 - 11/2017)
3.	Dawson, Keith M: 2 articles (10/2021 - 11/2017)
4.	Harstrick, Andreas: 2 articles (10/2021 - 03/2018)
5.	Zitt, Christof: 2 articles (10/2021 - 11/2017)
6.	Bakker, Talitha R: 2 articles (11/2017 - 11/2017)
7.	Cornelius, Andreas: 2 articles (11/2017 - 11/2017)
8.	Dolado, Ignacio: 2 articles (11/2017 - 11/2017)
9.	Ekawardhani, Savira: 2 articles (11/2017 - 11/2017)
10.	Azaro, Analía: 1 article (10/2021)

Related Diseases

1.	Neoplasms (Cancer) 10/01/2021 - "A multicenter, open-label, repeated-dose, phase I study was conducted to assess the safety, tolerability, and pharmacokinetics of MP0250 in 45 patients with advanced solid tumors. " 11/01/2017 - "MP0250 is a multi-domain drug candidate currently being tested in clinical trials for the treatment of cancer. " 11/17/2017 - "MP0250, a VEGF and HGF neutralizing DARPin® molecule shows high anti-tumor efficacy in mouse xenograft and patient-derived tumor models." 10/01/2021 - "First-in-Human Phase I Study of MP0250, a First-in-Class DARPin Drug Candidate Targeting VEGF and HGF, in Patients With Advanced Solid Tumors." 03/02/2018 - "In the syngeneic 5T33MM tumor model, MP0250 decreases the microvessel density (MVD) and the combination MP0250/bortezomib lowers the percentage of idiotype positive cells and the serum levels of M-protein. "
2.	Multiple Myeloma 03/02/2018 - "Here we studied the antiangiogenic effects of the MP0250 in multiple myeloma (MM). " 03/02/2018 - "Targeting angiogenesis in multiple myeloma by the VEGF and HGF blocking DARPin® protein MP0250: a preclinical study."

Related Drugs and Biologics

1.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
2.	Proteins (Proteins, Gene)
3.	Designed Ankyrin Repeat Proteins
4.	Bortezomib (Velcade)