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BJ-1301

aminopyridinol derivative of alpha-tocopherol; inhibits NADPH oxidase 2 (NOX2)

Networked: 1 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - Benzopyrans: 195
      - Vitamin E: 8680
        Tocopherols: 1861
        alpha-Tocopherol: 2941
        BJ-1301: 1
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzopyrans: 195
      - Vitamin E: 8680
        Tocopherols: 1861
        alpha-Tocopherol: 2941
        BJ-1301: 1

Experts

1.	Banskota, Suhrid: 1 article (10/2017)
2.	Gautam, Jaya: 1 article (10/2017)
3.	Jeong, Byeong-Seon: 1 article (10/2017)
4.	Jeong, Hyunyoung: 1 article (10/2017)
5.	Kim, Jung-Ae: 1 article (10/2017)
6.	Ku, Jin-Mo: 1 article (10/2017)
7.	Nam, Tae-Gyu: 1 article (10/2017)
8.	Park, Myo-Hyeon: 1 article (10/2017)
9.	Regmi, Sushil Chandra: 1 article (10/2017)
10.	Wang, Ying: 1 article (10/2017)

Related Diseases

1.	Lung Neoplasms (Lung Cancer) 10/01/2017 - "Taken together, the current study demonstrates that BJ-1301 is a promising anticancer drug for the treatment of lung cancer. " 10/01/2017 - "Dual Inhibition of NOX2 and Receptor Tyrosine Kinase by BJ-1301 Enhances Anticancer Therapy Efficacy via Suppression of Autocrine-Stimulatory Factors in Lung Cancer." 10/01/2017 - "In this study, we report that BJ-1301, a hybrid of pyridinol and alpha-tocopherol, exerts anticancer effects by dual inhibition of NADPH oxidase and RTK activities in endothelial and lung cancer cells. " 10/01/2017 - "Consistently, BJ-1301 inhibited cisplatin-resistant lung cancer cell proliferation more than sunitinib did. "
2.	Neoplasms (Cancer) 10/01/2017 - "Treatments with BJ-1301 induced regression of tumor growth, potentially due to downregulation of autocrine-stimulatory ligands for RTKs, such as TGFα and stem cell factor, in tumor tissues. " 10/01/2017 - "In xenograft chick or mouse tumor models, BJ-1301 inhibited lung tumor growth, to an extent greater than that of sunitinib or cisplatin. "

Related Drugs and Biologics

1.	alpha-Tocopherol
2.	NADPH Oxidases (NAD(P)H oxidase)
3.	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)
4.	Stem Cell Factor
5.	Ligands
6.	Cisplatin (Platino)
7.	Sunitinib (Sutent)

Related Therapies and Procedures

1.	Therapeutics