momfluorothrin

a nongenotoxic synthetic pyrethroid; induced hepatocellular tumors in male and female Wistar rats

Also Known As:

2,3,5,6-tetrafluoro-4-(methoxymethyl)benzyl(Z)-(1R,3R)-3-(2-cyanoprop-1-enyl)-2,2-dimethylcyclopropanecarboxylate

Networked: 2 relevant articles (0 outcomes, 2 trials/studies)

1.	Cohen, Samuel M: 2 articles (01/2017 - 01/2017)
2.	Higuchi, Hashihiro: 2 articles (01/2017 - 01/2017)
3.	Kawamura, Satoshi: 2 articles (01/2017 - 01/2017)
4.	Kushida, Masahiko: 2 articles (01/2017 - 01/2017)
5.	Lake, Brian G: 2 articles (01/2017 - 01/2017)
6.	Nakamura, Yoshimasa: 2 articles (01/2017 - 01/2017)
7.	Okuda, Yu: 2 articles (01/2017 - 01/2017)
8.	Yamada, Tomoya: 2 articles (01/2017 - 01/2017)
9.	Kikumoto, Hiroko: 1 article (01/2017)
10.	Nagahori, Hirohisa: 1 article (01/2017)

1.	Neoplasms (Cancer) 01/01/2017 - "As human hepatocytes are refractory to the mitogenic effects of momfluorothrin, in contrast to rat hepatocytes, the data support the hypothesis that the MOA for momfluorothrin-induced rat liver tumor formation is not relevant for humans." 01/01/2017 - "Overall, these data strongly support that the postulated MOA for momfluorothrin-induced rat hepatocellular tumors as being mediated by CAR activation." 01/01/2017 - "Mechanistic studies have demonstrated that the mode of action (MOA) for momfluorothrin-induced hepatocellular tumors is constitutive androstane receptor (CAR)-mediated. " 01/01/2017 - "To elucidate the MOA for rat hepatocellular tumor formation by momfluorothrin, this study was conducted to examine effects on key and associative events of the CAR-mediated MOA for phenobarbital based on the International Programme on Chemical Safety framework. " 01/01/2017 - "High dietary levels of the non-genotoxic synthetic pyrethroid momfluorothrin increased the incidence of hepatocellular tumors in male and female Wistar rats. "
2.	Hypertrophy 01/01/2017 - "A 2-week in vivo study in Wistar rats revealed that momfluorothrin induced CYP2B activities, increased liver weights, produced hepatocyte hypertrophy and increased hepatocyte replicative DNA synthesis. "

1.	Constitutive Androstane Receptor
2.	Phenobarbital (Luminal)
3.	DNA (Deoxyribonucleic Acid)
4.	Pyrethrins (Pyrethroids)
5.	(2,3,5,6- tetrafluoro- 4- methoxymethylphenyl)methyl- 2,2- dimethyl- 3- (1- propenyl)cyclopropanecarboxylate