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1- dodecylsulfonyl- 5N,6O- oxomethylidenenojirimycin

has anti-inflammatory activity in mouse retinal explants

Also Known As:

DSO2-ONJ

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Carbohydrates: 22023
- Glycoconjugates: 1353
  - Glycolipids: 2799
    - 1-dodecylsulfonyl-5N,6O-oxomethylidenenojirimycin: 2
Lipids: 114793
- Glycolipids: 2799
  - 1-dodecylsulfonyl-5N,6O-oxomethylidenenojirimycin: 2

Experts

1.	Sánchez-Fernández, Elena M: 2 articles (05/2019 - 01/2018)
2.	Duval, Monique: 1 article (05/2019)
3.	Fauny, Jean-Daniel: 1 article (05/2019)
4.	Flacher, Vincent: 1 article (05/2019)
5.	García Fernández, José M: 1 article (05/2019)
6.	Gonçalves-Pereira, Rita: 1 article (05/2019)
7.	Lamon, Delphine: 1 article (05/2019)
8.	Mueller, Christopher G: 1 article (05/2019)
9.	Ortiz Mellet, Carmen: 1 article (05/2019)
10.	Schaeffer, Evelyne: 1 article (05/2019)

Related Diseases

1.	Inflammation (Inflammations) 05/01/2019 - "Immunovisualization experiments, using a mannoside glycolipid conjugate (MGC) that also suppress LPS-mediated DC activation as control, evidenced a distinct mode of action for the sp2-IGLs: unlike MGCs, DSO2-ONJ did not elicit internalization of the LPS co-receptor CD14 or induce its co-localization with the Toll-like receptor 4. In a mouse model of LPS-induced acute inflammation, DSO2-ONJ demonstrated anti-inflammatory activity by inhibiting the production of the pro-inflammatory interleukin-6. "
2.	Gliosis 01/01/2018 - "In retinal explants from db/db mice, DSO2-ONJ also induced HO-1 and reduced gliosis. "

Related Drugs and Biologics

1.	Toll-Like Receptor 4
2.	Interleukin-6 (Interleukin 6)
3.	Retinaldehyde (Retinal)
4.	Mannosides
5.	Glycolipids