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gamitrinib-triphenylphosphonium

inhibits tumor necrosis factor receptor-associated protein 1 (TRAP1); increases glutamine synthetase activity in auxotrophic NSCLC cells

Also Known As:

G-TPP compound

Networked: 5 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Terphenyl Compounds: 1
        gamitrinib-triphenylphosphonium: 5
Polycyclic Compounds: 6
- Macrocyclic Compounds: 15
  - gamitrinib-triphenylphosphonium: 5

Experts

1.	Dong, Delu: 1 article (11/2021)
2.	Gao, Yufei: 1 article (11/2021)
3.	Huang, Renxuan: 1 article (11/2021)
4.	Sun, Liankun: 1 article (11/2021)
5.	Wang, Nan: 1 article (11/2021)
6.	Zhu, Peining: 1 article (11/2021)
7.	Choi, Jong-Whan: 1 article (01/2018)
8.	Hua, Tuyen N M: 1 article (01/2018)
9.	Jeong, Yangsik: 1 article (01/2018)
10.	Jung, Soon-Hee: 1 article (01/2018)

Related Diseases

1.	Glioblastoma (Glioblastoma Multiforme) 11/01/2021 - "TRAP1 inhibitor Gamitrinib triphenylphosphonium (G-TPP) and shRNA were used in the present study to suppress the function of this molecule in glioblastoma multiforme (GBM) cell lines. "
2.	Neoplasms (Cancer) 11/28/2022 - "To further elucidate the mechanistic role of TRAP1 in regulating tumor cell survival, we used gamitrinib-triphenylphosphonium (G-TPP) to inhibit TRAP1 signaling pathways in colon cancer. " 12/05/2017 - "Here, we used the mitochondrial targeted HSP90 inhibitor Gamitrinib-triphenylphosphonium (G-TPP), an anti-cancer agent, to chemically interfere with mitochondrial protein folding. "
3.	Mitochondrial Diseases (Mitochondrial Disease) 01/22/2016 - "Gamitrinib-triphenylphosphonium, a mitochondria-targeted Hsp90 inhibitor that increases cell death in HeLa and MCF7 cells, consistently inhibited cell death induced by oxidative stress and mitochondrial dysfunction induced by PINK1 mutation in mouse embryonic fibroblast cells and DA cell models such as SH-SY5Y and SN4741 cells. "
4.	Colonic Neoplasms (Colon Cancer) 11/28/2022 - "To further elucidate the mechanistic role of TRAP1 in regulating tumor cell survival, we used gamitrinib-triphenylphosphonium (G-TPP) to inhibit TRAP1 signaling pathways in colon cancer. "
5.	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/01/2018 - "Here we investigated the different susceptibility of glutamine-independent and glutamine-dependent non-small cell lung cancer (NSCLC) to treatment with tumor necrosis factor receptor-associated protein 1 (TRAP1) inhibitor gamitrinib-triphenylphosphonium (G-TPP). "

Related Drugs and Biologics

1.	Small Interfering RNA (siRNA)
2.	Mitochondrial Proteins (Mitochondrial Protein)
3.	Tumor Necrosis Factor Receptors (Tumor Necrosis Factor Receptor)
4.	Proteins (Proteins, Gene)
5.	Glutamine (L-Glutamine)