WY-135

Anaplastic lymphoma kinase inhibitor; structure in first source

Also Known As:

5-chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(2-methoxy-4-(4-((4-methylpiperazin-1-yl)methyl)-1H-1,2,3-triazol-1-yl)phenyl)pyrimidine-2,4-diamine

Networked: 1 relevant articles (1 outcomes, 1 trials/studies)

1.	Neoplasms (Cancer) 03/25/2018 - "WY-135 is a promising ALK inhibitor with novel structure that has tremendous potentials for therapeutic treatment of NPM-ALK or EML4-ALK positive cancers." 03/25/2018 - "Taken together, WY-135 exhibits significant anti-cancer activity through inhibiting ALK and its downstream protein expression, arresting cell cycle and eventually inducing cell apoptosis in Karpas299 and H2228 cells. " 03/25/2018 - "In this study, we investigated the anti-cancer effect of 5-chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(2-methoxy-4-(4-((4-methylpiperazin-1-yl)methyl)-1H-1,2,3-triazol-1-yl)phenyl)pyrimidine-2,4-diamine (WY-135), a novel ALK inhibitor, on nucleophosmin-anaplastic lymphoma kinase (NPM-ALK) positive cancer cell line Karpas299 and echinoderm microtubule associated protein like 4-anaplastic lymphoma kinase (EML4-ALK) positive cancer cell line H2228. "
2.	Lymphoma (Lymphomas) 03/25/2018 - "In this study, we investigated the anti-cancer effect of 5-chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(2-methoxy-4-(4-((4-methylpiperazin-1-yl)methyl)-1H-1,2,3-triazol-1-yl)phenyl)pyrimidine-2,4-diamine (WY-135), a novel ALK inhibitor, on nucleophosmin-anaplastic lymphoma kinase (NPM-ALK) positive cancer cell line Karpas299 and echinoderm microtubule associated protein like 4-anaplastic lymphoma kinase (EML4-ALK) positive cancer cell line H2228. "

1.	Anaplastic Lymphoma Kinase
2.	Phosphotransferases (Kinase)
3.	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)
4.	Proteins (Proteins, Gene)