DIMP53-1
tryptophanol-derived oxazoloisoindolinone; a small-molecule dual inhibitor of p53-MDM2/X interactions with multifunctional p53-dependent anticancer properties; structure in first source
Networked: 1
relevant articles (0 outcomes,
0 trials/studies)
Bio-Agent Context: Research Results
Experts
| 1. | Espadinha, Margarida:
1 article
(01/2017)
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| 2. | Gomes, Ana Sara:
1 article
(01/2017)
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| 3. | Gomes, Célia:
1 article
(01/2017)
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| 4. | Gomes, Sara:
1 article
(01/2017)
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| 5. | Inga, Alberto:
1 article
(01/2017)
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| 6. | Loureiro, Joana B:
1 article
(01/2017)
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| 7. | Raimundo, Liliana:
1 article
(01/2017)
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| 8. | Ramos, Helena:
1 article
(01/2017)
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| 9. | Reis, Flávio:
1 article
(01/2017)
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| 10. | Santos, Maria M M:
1 article
(01/2017)
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Related Diseases
| 1. | Neoplasms (Cancer)
01/01/2017
- " Although target-directed, DIMP53-1 has a multifunctional activity, targeting major hallmarks of cancer through its antiproliferative, proapoptotic, antiangiogenic, anti-invasive, and antimigratory properties. " 01/01/2017
- " Notably, in human tumor xenograft mice models, DIMP53-1 showed a p53-dependent antitumor activity through induction of apoptosis and inhibition of proliferation and angiogenesis. " 01/01/2017
- " DIMP53-1 caused growth inhibition, mediated by p53 stabilization and upregulation of p53 transcriptional targets involved in cell cycle arrest and apoptosis, in wt p53-expressing tumor cells, including MDM2- or MDMX-overexpressing cells. "
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| 2. | Colonic Neoplasms (Colon Cancer)
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