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XL388

antineoplastic; structure in first source

Networked: 6 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Sulfur Compounds: 278
  - Sulfones: 534
    - XL388: 6

Experts

1.	Zhong, Shan: 2 articles (11/2020 - 05/2017)
2.	Cha, Myeounghoon: 2 articles (01/2020 - 01/2020)
3.	Choi, Songyeon: 2 articles (01/2020 - 01/2020)
4.	Kim, Kyeongmin: 2 articles (01/2020 - 01/2020)
5.	Lee, Bae Hwan: 2 articles (01/2020 - 01/2020)
6.	Amin, Anubhav G: 1 article (10/2021)
7.	Gandhi, Chirag D: 1 article (10/2021)
8.	Gillick, John L: 1 article (10/2021)
9.	Jeong, Seung Won: 1 article (10/2021)
10.	Jhanwar-Uniyal, Meena: 1 article (10/2021)

Related Diseases

1.	Osteosarcoma (Osteogenic Sarcoma) 08/02/2016 - "The anti-cancer activity of the mTORC1/2 dual inhibitor XL388 in preclinical osteosarcoma models." 08/02/2016 - "In the present study, we investigated the activity of XL388, a novel mammalian target of rapamycin (mTOR) complex 1/2 (mTORC1/2) dual inhibitor, in preclinical osteosarcoma (OS) models. "
2.	Neuralgia (Stump Neuralgia) 01/01/2020 - "This study was conducted to determine the inhibitory effects of Torin1 and XL388 in an animal model of neuropathic pain. " 01/01/2020 - "mTOR signaling intervention by Torin1 and XL388 in the insular cortex alleviates neuropathic pain." 01/01/2020 - "These results strongly suggest that Torin1 and XL388 may attenuate neuropathic pain via inhibition of mTORC1 and mTORC2 in the IC."
3.	Neoplasms (Cancer) 08/02/2016 - "The anti-cancer activity of the mTORC1/2 dual inhibitor XL388 in preclinical osteosarcoma models." 05/02/2017 - "In vivo, oral administration of XL388 inhibited in nude mice 786-0 RCC tumor growth, and its anti-tumor activity was sensitized with co-administration of the MEK-ERK inhibitor MEK162. "
4.	Pain (Aches) 01/01/2020 - "Therefore, we aimed to determine the pain-relieving effect of mTOR inhibitors (Torin1 and XL388) and observe the changes in optical signals in the IC after treatment. "
5.	Hyperalgesia 01/01/2020 - "Administration of Torin1 or XL388 into the IC significantly increased mechanical thresholds and reduced mechanical allodynia. "

Related Drugs and Biologics

1.	Mechanistic Target of Rapamycin Complex 1
2.	TOR Serine-Threonine Kinases
3.	Mechanistic Target of Rapamycin Complex 2
4.	Basic-Leucine Zipper Transcription Factors
5.	Mitogen-Activated Protein Kinase Kinases (MEKs)
6.	Phosphotransferases (Kinase)
7.	MTOR Inhibitors
8.	binimetinib

Related Therapies and Procedures

1.	Aftercare (After-Treatment)
2.	Oral Administration