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PF-06840003

an inhibitor of indoleamine 2,3-dioxygenase; structure in first source

Also Known As:

3-(5-fluoro-1H-indol-3-yl)pyrrolidine-2,5-dione; EOS200271

Networked: 3 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrrolidines: 115
    - Pyrrolidinones: 162
      - Succinimides: 11
        PF-06840003: 3
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - PF-06840003: 3
Organic Chemicals: 133
- Imides: 79
  - Succinimides: 11
    - PF-06840003: 3

Experts

1.	Gao, Zhanqun: 1 article (01/2021)
2.	Li, Shuang: 1 article (01/2021)
3.	Li, Shuangjia: 1 article (01/2021)
4.	Li, Yanmei: 1 article (01/2021)
5.	Liu, Yang: 1 article (01/2021)
6.	Tan, Qingyun: 1 article (01/2021)
7.	Wang, Dongwei: 1 article (01/2021)
8.	Wang, Qingdong: 1 article (01/2021)
9.	Alekar, Shilpa: 1 article (12/2020)
10.	Cloughesy, Timothy: 1 article (12/2020)

Related Diseases

1.	Neoplasms (Cancer) 12/01/2018 - "It reversed IDO1-induced T-cell anergy in vitro In mice carrying syngeneic tumor grafts, PF-06840003 reduced intratumoral kynurenine levels by over 80% and inhibited tumor growth both in monotherapy and, with an increased efficacy, in combination with antibodies blocking the immune checkpoint ligand PD-L1. "
2.	Glioma (Gliomas) 12/01/2020 - "A phase 1 study of PF-06840003, an oral indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor in patients with recurrent malignant glioma."
3.	Cardiomegaly (Heart Hypertrophy) 01/01/2021 - "Inhibition of IDO1 activity with PF-06840003 reduced Ang II-induced cardiac hypertrophy and rescued cardiac function in mice. "

Related Drugs and Biologics

1.	Blocking Antibodies
2.	Ligands
3.	Kynurenine
4.	Indoleamine-Pyrrole 2,3,-Dioxygenase (Indoleamine 2,3 Dioxygenase)