BK10007S

has antineoplastic activity; structure in first source

Networked: 1 relevant articles (0 outcomes, 1 trials/studies)

1.	Hepatocellular Carcinoma (Hepatoma) 01/01/2017 - "Thus, in the present study, the antitumor mechanism of BK10007S was elucidated in hepatocellular carcinoma cells (HCCs). " 01/01/2017 - "Overall, these findings provide scientific evidences that BK10007S induces apoptosis via inhibition of CUGBP1 and activation of caspases in hepatocellular carcinomas as a potent anticancer candidate." 01/01/2017 - "Inhibition of CUG-binding protein 1 and activation of caspases are critically involved in piperazine derivative BK10007S induced apoptosis in hepatocellular carcinoma cells."
2.	Pancreatic Neoplasms (Pancreatic Cancer) 01/01/2017 - "Though piperazine derivative BK10007S was known to induce apoptosis in pancreatic cancer xenograft model as a T-type CaV3.1 a1G isoform calcium channel blocker, its underlying antitumor mechanism still remains unclear so far. "

1.	Caspases
2.	Protein Isoforms (Isoforms)
3.	Carrier Proteins (Binding Protein)
4.	Calcium Channel Blockers (Blockers, Calcium Channel)
5.	Piperazine